The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease

Fred De Winter, Tam Vo, Floor J Stam, Liselijn A B Wisman, Peter R Bär, Simone P Niclou, Freek L van Muiswinkel, J. Verhaagen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Neuromuscular synapses differ markedly in their plasticity. Motor nerve terminals innervating slow muscle fibers sprout vigorously following synaptic blockage, while those innervating fast-fatigable muscle fibers fail to exhibit any sprouting. Here, we show that the axon repellent Semaphorin 3A is differentially expressed in terminal Schwann cells (TSCs) on different populations of muscle fibers: postnatal, regenerative and paralysis induced remodeling of neuromuscular connections is accompanied by increased expression of Sema3A selectively in TSCs on fast-fatigable muscle fibers. To our knowledge, this is the first demonstration of a molecular difference between TSCs on neuromuscular junctions of different subtypes of muscle fibers. Interestingly, also in a mouse model for amyotrophic lateral sclerosis (ALS), Sema3A is expressed at NMJs of fast-fatigable muscle fibers. We propose that expression of Sema3A by TSCs not only suppresses nerve terminal plasticity at specific neuromuscular synapses, but may also contribute to their early and selective loss in the motor neuron disease ALS.

Original languageEnglish
Pages (from-to)102-17
Number of pages16
JournalMolecular and Cellular Neurosciences
Volume32
Issue number1-2
DOIs
Publication statusPublished - 09 May 2006

Keywords

  • Animals
  • Cell Survival
  • Denervation
  • Disease Models, Animal
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Mice
  • Mice, Transgenic
  • Motor Neuron Disease
  • Motor Neurons
  • Muscle Fibers, Skeletal
  • Muscle, Skeletal
  • Nerve Degeneration
  • Neuromuscular Junction
  • Neuronal Plasticity
  • Rats
  • Rats, Wistar
  • Schwann Cells
  • Sciatic Neuropathy
  • Semaphorin-3A
  • Superoxide Dismutase
  • Superoxide Dismutase-1
  • Journal Article

Fingerprint

Dive into the research topics of 'The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease'. Together they form a unique fingerprint.

Cite this