The frontier of live tissue imaging across space and time

Qiang Huang, Aliesha Garrett, Shree Bose, Stephanie Blocker, Anne C Rios, Hans Clevers, Xiling Shen

Research output: Contribution to journal/periodicalBook/Film/Article reviewScientific

17 Citations (Scopus)


What you see is what you get-imaging techniques have long been essential for visualization and understanding of tissue development, homeostasis, and regeneration, which are driven by stem cell self-renewal and differentiation. Advances in molecular and tissue modeling techniques in the last decade are providing new imaging modalities to explore tissue heterogeneity and plasticity. Here we describe current state-of-the-art imaging modalities for tissue research at multiple scales, with a focus on explaining key tradeoffs such as spatial resolution, penetration depth, capture time/frequency, and moieties. We explore emerging tissue modeling and molecular tools that improve resolution, specificity, and throughput.

Original languageEnglish
Pages (from-to)603-622
Number of pages20
JournalCell Stem Cell
Issue number4
Publication statusPublished - 01 Apr 2021


  • Cell Differentiation


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