The human histaminergic system in neuropsychiatric disorders

Ling Shan; Ai-Min Bao; Dick F Swaab

doi:10.1016/j.tins.2014.12.008

The human histaminergic system in neuropsychiatric disorders

Ling Shan, Ai-Min Bao, Dick F Swaab

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

84 Citations (Scopus)

Abstract

Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus, from where they project to many brain areas. The histaminergic system is involved in basic physiological functions, such as the sleep-wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, and attention, which are all severely affected in neuropsychiatric disorders. Here, we present recent postmortem findings on the alterations in this system in neuropsychiatric disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), depression, and narcolepsy. In addition, we highlight the need to validate animal models for these diseases and also for Tourette's syndrome (TS) in relation to alterations in the histaminergic system. Moreover, we discuss the potential for, and concerns over, the use of novel histamine 3 receptor (H3R) antagonists/inverse agonists as treatment for such disorders.

Original language	English
Pages (from-to)	167-177
Number of pages	11
Journal	Trends in Neurosciences
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.tins.2014.12.008
Publication status	Published - Mar 2015

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The human histaminergic system in neuropsychiatric disorders

Abstract

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