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The human histaminergic system in neuropsychiatric disorders. / Shan, Ling; Bao, Ai-Min; Swaab, Dick F.

In: Trends in Neurosciences, Vol. 38, No. 3, 03.2015, p. 167-177.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Harvard

Shan, L, Bao, A-M & Swaab, DF 2015, 'The human histaminergic system in neuropsychiatric disorders' Trends in Neurosciences, vol. 38, no. 3, pp. 167-177. DOI: 10.1016/j.tins.2014.12.008

APA

Vancouver

Shan L, Bao A-M, Swaab DF. The human histaminergic system in neuropsychiatric disorders. Trends in Neurosciences. 2015 Mar;38(3):167-177. Available from, DOI: 10.1016/j.tins.2014.12.008

Author

Shan, Ling ; Bao, Ai-Min ; Swaab, Dick F. / The human histaminergic system in neuropsychiatric disorders. In: Trends in Neurosciences. 2015 ; Vol. 38, No. 3. pp. 167-177

BibTeX

@article{89d466a4a63f49f4a44b631fbd752d01,
title = "The human histaminergic system in neuropsychiatric disorders",
abstract = "Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus, from where they project to many brain areas. The histaminergic system is involved in basic physiological functions, such as the sleep-wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, and attention, which are all severely affected in neuropsychiatric disorders. Here, we present recent postmortem findings on the alterations in this system in neuropsychiatric disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), depression, and narcolepsy. In addition, we highlight the need to validate animal models for these diseases and also for Tourette's syndrome (TS) in relation to alterations in the histaminergic system. Moreover, we discuss the potential for, and concerns over, the use of novel histamine 3 receptor (H3R) antagonists/inverse agonists as treatment for such disorders.",
author = "Ling Shan and Ai-Min Bao and Swaab, {Dick F}",
note = "Copyright {\circledC} 2014 Elsevier Ltd. All rights reserved.",
year = "2015",
month = "3",
doi = "10.1016/j.tins.2014.12.008",
language = "English",
volume = "38",
pages = "167--177",
journal = "Trends in Neurosciences",
issn = "0166-2236",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - The human histaminergic system in neuropsychiatric disorders

AU - Shan,Ling

AU - Bao,Ai-Min

AU - Swaab,Dick F

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2015/3

Y1 - 2015/3

N2 - Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus, from where they project to many brain areas. The histaminergic system is involved in basic physiological functions, such as the sleep-wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, and attention, which are all severely affected in neuropsychiatric disorders. Here, we present recent postmortem findings on the alterations in this system in neuropsychiatric disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), depression, and narcolepsy. In addition, we highlight the need to validate animal models for these diseases and also for Tourette's syndrome (TS) in relation to alterations in the histaminergic system. Moreover, we discuss the potential for, and concerns over, the use of novel histamine 3 receptor (H3R) antagonists/inverse agonists as treatment for such disorders.

AB - Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus, from where they project to many brain areas. The histaminergic system is involved in basic physiological functions, such as the sleep-wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, and attention, which are all severely affected in neuropsychiatric disorders. Here, we present recent postmortem findings on the alterations in this system in neuropsychiatric disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), depression, and narcolepsy. In addition, we highlight the need to validate animal models for these diseases and also for Tourette's syndrome (TS) in relation to alterations in the histaminergic system. Moreover, we discuss the potential for, and concerns over, the use of novel histamine 3 receptor (H3R) antagonists/inverse agonists as treatment for such disorders.

U2 - 10.1016/j.tins.2014.12.008

DO - 10.1016/j.tins.2014.12.008

M3 - Article

VL - 38

SP - 167

EP - 177

JO - Trends in Neurosciences

T2 - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0166-2236

IS - 3

ER -

ID: 982338