The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism

Benjamin Metz, Ronald P de Vries, Stefan Polak, Verena Seidl, Bernhard Seiboth

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    Abstract

    The Hypocrea jecorina LXR1 was described as the first fungal L-xylulose reductase responsible for NADPH dependent reduction of L-xylulose to xylitol in L-arabinose catabolism. Phylogenetic analysis now reveals that LXR1 forms a clade with fungal D-mannitol 2-dehydrogenases. Lxr1 and the orthologous Aspergillus niger mtdA are not induced by L-arabinose but expressed at low levels during growth on different carbon sources. Deletion of lxr1 does not affect growth on L-arabinose and L-xylulose reductase activity remains unaltered whereas D-mannitol 2-dehydrogenase activities are reduced. We conclude that LXR1 is a D-mannitol 2-dehydrogenase and that a true LXR1 is still awaiting discovery.

    Original languageEnglish
    Pages (from-to)1309-13
    Number of pages5
    JournalFEBS Letters
    Volume583
    Issue number8
    DOIs
    Publication statusPublished - 17 Apr 2009

    Keywords

    • Arabinose
    • Genes, Fungal
    • Mannitol Dehydrogenases
    • Trichoderma

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