The hypothalamus and its role in hypertension

TY - JOUR

T1 - The hypothalamus and its role in hypertension

AU - Goncharuk, Valeri D

N1 - Copyright © 2021 Elsevier B.V. All rights reserved.

PY - 2021

Y1 - 2021

N2 - For the majority of hypertensive patients, the etiology of their disease is unknown. The hypothalamus is a central structure of the brain which provides an adaptive, integrative, autonomic, and neuroendocrine response to any fluctuations in physiological conditions of the external or internal environment. Hypothalamic insufficiency leads to severe metabolic and functional disorders, including persistent increase in blood pressure. Here, we discuss alterations in the neurochemical organization of the paraventricular and suprachiasmatic nucleus in the hypothalamus of patients who suffered from essential hypertension and died suddenly due to acute coronary failure. The changes observed are hypothesized to contribute to the pathogenesis of disease.

AB - For the majority of hypertensive patients, the etiology of their disease is unknown. The hypothalamus is a central structure of the brain which provides an adaptive, integrative, autonomic, and neuroendocrine response to any fluctuations in physiological conditions of the external or internal environment. Hypothalamic insufficiency leads to severe metabolic and functional disorders, including persistent increase in blood pressure. Here, we discuss alterations in the neurochemical organization of the paraventricular and suprachiasmatic nucleus in the hypothalamus of patients who suffered from essential hypertension and died suddenly due to acute coronary failure. The changes observed are hypothesized to contribute to the pathogenesis of disease.

U2 - 10.1016/B978-0-12-819973-2.00023-X

DO - 10.1016/B978-0-12-819973-2.00023-X

M3 - Article

C2 - 34266604

SN - 0072-9752

VL - 182

SP - 333

EP - 354

JO - Handbook of Clinical Neurology

JF - Handbook of Clinical Neurology

ER -