The intestinal crypt, a prototype stem cell compartment

TY - JOUR

T1 - The intestinal crypt, a prototype stem cell compartment

AU - Clevers, H.

N1 - Reporting year: 2013

PY - 2013

Y1 - 2013

N2 - Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal epithelium has become a prime model for studying adult stem cells in health and disease. Transgenic mouse models allow in vivo visualization and genetic lineage tracing of individual intestinal stem cells and their offspring. Fluorescently marked stem cells can be isolated for molecular analyses or can be cultured to build ever-expanding "mini-guts" in vitro. These studies are filling in the outlines of a robust homeostatic self-renewal process that defies some of the classical definitions of stem cell behavior, such as asymmetric division, quiescence, and exhaustion.

AB - Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal epithelium has become a prime model for studying adult stem cells in health and disease. Transgenic mouse models allow in vivo visualization and genetic lineage tracing of individual intestinal stem cells and their offspring. Fluorescently marked stem cells can be isolated for molecular analyses or can be cultured to build ever-expanding "mini-guts" in vitro. These studies are filling in the outlines of a robust homeostatic self-renewal process that defies some of the classical definitions of stem cell behavior, such as asymmetric division, quiescence, and exhaustion.

U2 - 10.1016/j.cell.2013.07.004

DO - 10.1016/j.cell.2013.07.004

M3 - Article

SN - 0092-8674

VL - 154

SP - 274

EP - 284

JO - Cell

JF - Cell

IS - 2

ER -