The microRNA-producing enzyme Dicer1 is essential for zebrafish development

E. Wienholds, M.J. Koudijs, F. van Eeden, E. Cuppen, R. Plasterk

Research output: Contribution to journal/periodicalArticleScientificpeer-review

377 Citations (Scopus)


MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.
Original languageEnglish
Pages (from-to)217-218
JournalNature Genetics
Issue number3
Publication statusPublished - 2003


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