The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19

Maarten H Geurts, Jelte van der Vaart, Joep Beumer, Hans Clevers

Research output: Contribution to journal/periodicalBook/Film/Article reviewScientific

Abstract

Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closely mimic human physiology. In the current COVID-19 pandemic, rapid scientific insights are of the utmost importance to limit its impact on public health and society. Organoids are emerging as versatile tools to progress the understanding of SARS-CoV-2 biology and to aid in the quest for novel treatments.

Original languageEnglish
Pages (from-to)412-418
Number of pages7
JournalStem Cell Reports
Volume16
Issue number3
DOIs
Publication statusPublished - 09 Mar 2021

Keywords

  • Animals
  • COVID-19/virology
  • Humans
  • Organoids/virology
  • Pandemics/prevention & control
  • SARS-CoV-2/pathogenicity

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