The photobiology of the human circadian clock

Robin A Schoonderwoerd; Mischa de Rover; Jan A M Janse; Lydiane Hirschler; Channa R Willemse; Leonie Scholten; Ilse Klop; Sander van Berloo; Matthias J P van Osch; Dick F Swaab; Johanna H Meijer

doi:10.1073/pnas.2118803119

The photobiology of the human circadian clock

Robin A Schoonderwoerd, Mischa de Rover, Jan A M Janse, Lydiane Hirschler, Channa R Willemse, Leonie Scholten, Ilse Klop, Sander van Berloo, Matthias J P van Osch, Dick F Swaab, Johanna H Meijer

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

5 Downloads (Pure)

Abstract

SignificanceThe function of our biological clock is dependent on environmental light. Rodent studies have shown that there are multiple colors that affect the clock, but indirect measures in humans suggest blue light is key. We performed functional MRI studies in human subjects with unprecedented spatial resolution to investigate color sensitivity of our clock. Here, we show that narrowband blue, green, and orange light were all effective in changing neuronal activity of the clock. While the clock of nocturnal rodents is excited by light, the human clock responds with a decrease in neuronal activity as indicated by a negative BOLD response. The sensitivity of the clock to multiple colors should be integrated in light therapy aimed to strengthen our 24-h rhythms.

Original language	English
Pages (from-to)	e2118803119
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	13
DOIs	https://doi.org/10.1073/pnas.2118803119
Publication status	Published - 29 Mar 2022

Access to Document

10.1073/pnas.2118803119

Schoonderwoerd2022Final published version, 1.49 MB

Cite this

Schoonderwoerd, R. A., de Rover, M., Janse, J. A. M., Hirschler, L., Willemse, C. R., Scholten, L., Klop, I., van Berloo, S., van Osch, M. J. P., Swaab, D. F., & Meijer, J. H. (2022). The photobiology of the human circadian clock. Proceedings of the National Academy of Sciences of the United States of America, 119(13), e2118803119. https://doi.org/10.1073/pnas.2118803119

@article{966d2539c1c046b9b2bb3812477222f0,

title = "The photobiology of the human circadian clock",

abstract = "SignificanceThe function of our biological clock is dependent on environmental light. Rodent studies have shown that there are multiple colors that affect the clock, but indirect measures in humans suggest blue light is key. We performed functional MRI studies in human subjects with unprecedented spatial resolution to investigate color sensitivity of our clock. Here, we show that narrowband blue, green, and orange light were all effective in changing neuronal activity of the clock. While the clock of nocturnal rodents is excited by light, the human clock responds with a decrease in neuronal activity as indicated by a negative BOLD response. The sensitivity of the clock to multiple colors should be integrated in light therapy aimed to strengthen our 24-h rhythms.",

author = "Schoonderwoerd, {Robin A} and {de Rover}, Mischa and Janse, {Jan A M} and Lydiane Hirschler and Willemse, {Channa R} and Leonie Scholten and Ilse Klop and {van Berloo}, Sander and {van Osch}, {Matthias J P} and Swaab, {Dick F} and Meijer, {Johanna H}",

year = "2022",

month = mar,

day = "29",

doi = "10.1073/pnas.2118803119",

language = "English",

volume = "119",

pages = "e2118803119",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "13",

}

TY - JOUR

T1 - The photobiology of the human circadian clock

AU - Schoonderwoerd, Robin A

AU - de Rover, Mischa

AU - Janse, Jan A M

AU - Hirschler, Lydiane

AU - Willemse, Channa R

AU - Scholten, Leonie

AU - Klop, Ilse

AU - van Berloo, Sander

AU - van Osch, Matthias J P

AU - Swaab, Dick F

AU - Meijer, Johanna H

PY - 2022/3/29

Y1 - 2022/3/29

N2 - SignificanceThe function of our biological clock is dependent on environmental light. Rodent studies have shown that there are multiple colors that affect the clock, but indirect measures in humans suggest blue light is key. We performed functional MRI studies in human subjects with unprecedented spatial resolution to investigate color sensitivity of our clock. Here, we show that narrowband blue, green, and orange light were all effective in changing neuronal activity of the clock. While the clock of nocturnal rodents is excited by light, the human clock responds with a decrease in neuronal activity as indicated by a negative BOLD response. The sensitivity of the clock to multiple colors should be integrated in light therapy aimed to strengthen our 24-h rhythms.

AB - SignificanceThe function of our biological clock is dependent on environmental light. Rodent studies have shown that there are multiple colors that affect the clock, but indirect measures in humans suggest blue light is key. We performed functional MRI studies in human subjects with unprecedented spatial resolution to investigate color sensitivity of our clock. Here, we show that narrowband blue, green, and orange light were all effective in changing neuronal activity of the clock. While the clock of nocturnal rodents is excited by light, the human clock responds with a decrease in neuronal activity as indicated by a negative BOLD response. The sensitivity of the clock to multiple colors should be integrated in light therapy aimed to strengthen our 24-h rhythms.

U2 - 10.1073/pnas.2118803119

DO - 10.1073/pnas.2118803119

M3 - Article

C2 - 35312355

SN - 0027-8424

VL - 119

SP - e2118803119

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 13

ER -

The photobiology of the human circadian clock

Abstract

Access to Document

Fingerprint

Cite this