The role of small non-coding RNAs in genome stability and chromatin organization

TY - JOUR

T1 - The role of small non-coding RNAs in genome stability and chromatin organization

AU - van Wolfswinkel, J.C.

AU - Ketting, R.F.

N1 - Reporting year: 2010

PY - 2010

Y1 - 2010

N2 - Small non-coding RNAs make up much of the RNA content of a cell and have the potential to regulate gene expression on many different levels. Initial discoveries in the 1990s and early 21st century focused on determining mechanisms of post-transcriptional regulation mediated by small-interfering RNAs (siRNAs) and microRNAs (miRNAs). More recent research, however, has identified new classes of RNAs and new regulatory mechanisms, expanding the known regulatory potential of small non-coding RNAs to encompass chromatin regulation. In this Commentary, we provide an overview of these chromatin-related mechanisms and speculate on the extent to which they are conserved among eukaryotes.

AB - Small non-coding RNAs make up much of the RNA content of a cell and have the potential to regulate gene expression on many different levels. Initial discoveries in the 1990s and early 21st century focused on determining mechanisms of post-transcriptional regulation mediated by small-interfering RNAs (siRNAs) and microRNAs (miRNAs). More recent research, however, has identified new classes of RNAs and new regulatory mechanisms, expanding the known regulatory potential of small non-coding RNAs to encompass chromatin regulation. In this Commentary, we provide an overview of these chromatin-related mechanisms and speculate on the extent to which they are conserved among eukaryotes.

U2 - 10.1242/jcs.061713

DO - 10.1242/jcs.061713

M3 - Article

SN - 0021-9533

VL - 123

SP - 1825

EP - 1839

JO - Journal of Cell Science

JF - Journal of Cell Science

IS - Pt 11

ER -