The role of the cerebellum in multiple sclerosis: structural damage and disconnecting networks

Emma JP Brouwer; Myrte Strik; Menno M. Schoonheim

doi:10.1016/j.cobeha.2024.101436

The role of the cerebellum in multiple sclerosis: structural damage and disconnecting networks

Emma JP Brouwer, Myrte Strik, Menno M. Schoonheim

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease of the central nervous system. Patterns of tissue damage in MS are not random, and some regions are more commonly and more severely affected than others. Gray matter changes in MS are highly clinically relevant and include neurodegeneration in the form of atrophy but also altered functional communication between brain areas. One important structure heavily affected by MS yet still understudied is the cerebellum. This structure has a complex cytoarchitecture and remains difficult to scan in vivo due to its heavily folded cortex and placement in the posterior fossa. Recent insights have shown that the cerebellum is not only involved in motor functioning but also has a clear role in cognitive performance, driven by its network connections to cognitive networks. This review outlines recent insights into cerebellar damage and cerebellar network changes in MS and focuses on their relevance for cognition.

Original language	English
Article number	101436
Journal	Current Opinion in Behavioral Sciences
Volume	59
DOIs	https://doi.org/10.1016/j.cobeha.2024.101436
Publication status	Published - Sept 2024

Access to Document

10.1016/j.cobeha.2024.101436

Cite this

@article{4abea8956d1a4dda968f6c322fa0baa0,

title = "The role of the cerebellum in multiple sclerosis: structural damage and disconnecting networks",

abstract = "Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease of the central nervous system. Patterns of tissue damage in MS are not random, and some regions are more commonly and more severely affected than others. Gray matter changes in MS are highly clinically relevant and include neurodegeneration in the form of atrophy but also altered functional communication between brain areas. One important structure heavily affected by MS yet still understudied is the cerebellum. This structure has a complex cytoarchitecture and remains difficult to scan in vivo due to its heavily folded cortex and placement in the posterior fossa. Recent insights have shown that the cerebellum is not only involved in motor functioning but also has a clear role in cognitive performance, driven by its network connections to cognitive networks. This review outlines recent insights into cerebellar damage and cerebellar network changes in MS and focuses on their relevance for cognition.",

author = "Brouwer, {Emma JP} and Myrte Strik and Schoonheim, {Menno M.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = sep,

doi = "10.1016/j.cobeha.2024.101436",

language = "English",

volume = "59",

journal = "Current Opinion in Behavioral Sciences",

issn = "2352-1546",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - The role of the cerebellum in multiple sclerosis

T2 - structural damage and disconnecting networks

AU - Brouwer, Emma JP

AU - Strik, Myrte

AU - Schoonheim, Menno M.

PY - 2024/9

Y1 - 2024/9

N2 - Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease of the central nervous system. Patterns of tissue damage in MS are not random, and some regions are more commonly and more severely affected than others. Gray matter changes in MS are highly clinically relevant and include neurodegeneration in the form of atrophy but also altered functional communication between brain areas. One important structure heavily affected by MS yet still understudied is the cerebellum. This structure has a complex cytoarchitecture and remains difficult to scan in vivo due to its heavily folded cortex and placement in the posterior fossa. Recent insights have shown that the cerebellum is not only involved in motor functioning but also has a clear role in cognitive performance, driven by its network connections to cognitive networks. This review outlines recent insights into cerebellar damage and cerebellar network changes in MS and focuses on their relevance for cognition.

AB - Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease of the central nervous system. Patterns of tissue damage in MS are not random, and some regions are more commonly and more severely affected than others. Gray matter changes in MS are highly clinically relevant and include neurodegeneration in the form of atrophy but also altered functional communication between brain areas. One important structure heavily affected by MS yet still understudied is the cerebellum. This structure has a complex cytoarchitecture and remains difficult to scan in vivo due to its heavily folded cortex and placement in the posterior fossa. Recent insights have shown that the cerebellum is not only involved in motor functioning but also has a clear role in cognitive performance, driven by its network connections to cognitive networks. This review outlines recent insights into cerebellar damage and cerebellar network changes in MS and focuses on their relevance for cognition.

UR - http://www.scopus.com/inward/record.url?scp=85200008466&partnerID=8YFLogxK

U2 - 10.1016/j.cobeha.2024.101436

DO - 10.1016/j.cobeha.2024.101436

M3 - Article

AN - SCOPUS:85200008466

SN - 2352-1546

VL - 59

JO - Current Opinion in Behavioral Sciences

JF - Current Opinion in Behavioral Sciences

M1 - 101436

ER -

The role of the cerebellum in multiple sclerosis: structural damage and disconnecting networks

Abstract

Access to Document

Other files and links

Cite this