The Sugar Metabolic Model of 
        Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum.

Jiajia Li; Tania Chroumpi; Sandra Garrigues; Roland S Kun; Jiali Meng; Sonia Salazar-Cerezo; Maria Victoria Aguilar-Pontes; Yu Zhang; Sravanthi Tejomurthula; Anna Lipzen; Vivian Ng; Chaevien S Clendinen; Nikola Tolić; Igor V Grigoriev; Adrian Tsang; Miia R Mäkelä; Berend Snel; Mao Peng; Ronald P de Vries

doi:10.3390/jof8121315

The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum.

Jiajia Li, Tania Chroumpi, Sandra Garrigues, Roland S Kun, Jiali Meng, Sonia Salazar-Cerezo, Maria Victoria Aguilar-Pontes, Yu Zhang, Sravanthi Tejomurthula, Anna Lipzen, Vivian Ng, Chaevien S Clendinen, Nikola Tolić, Igor V Grigoriev, Adrian Tsang, Miia R Mäkelä, Berend Snel, Mao Peng, Ronald P de Vries

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

Fungi play a critical role in the global carbon cycle by degrading plant polysaccharides to small sugars and metabolizing them as carbon and energy sources. We mapped the well-established sugar metabolic network of Aspergillus niger to five taxonomically distant species ( Aspergillus nidulans, Penicillium subrubescens, Trichoderma reesei, Phanerochaete chrysosporium and Dichomitus squalens) using an orthology-based approach. The diversity of sugar metabolism correlates well with the taxonomic distance of the fungi. The pathways are highly conserved between the three studied Eurotiomycetes ( A. niger, A. nidulans, P. subrubescens). A higher level of diversity was observed between the T. reesei and A. niger, and even more so for the two Basidiomycetes. These results were confirmed by integrative analysis of transcriptome, proteome and metabolome, as well as growth profiles of the fungi growing on the corresponding sugars. In conclusion, the establishment of sugar pathway models in different fungi revealed the diversity of fungal sugar conversion and provided a valuable resource for the community, which would facilitate rational metabolic engineering of these fungi as microbial cell factories.

Original language	English
Journal	Journal of Fungi
Volume	8
Issue number	12
DOIs	https://doi.org/10.3390/jof8121315
Publication status	Published - 17 Dec 2022

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10.3390/jof8121315

https://www.mdpi.com/2309-608X/8/12/1315Licence: Unspecified

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Li, J., Chroumpi, T., Garrigues, S., Kun, R. S., Meng, J., Salazar-Cerezo, S., Aguilar-Pontes, M. V., Zhang, Y., Tejomurthula, S., Lipzen, A., Ng, V., Clendinen, C. S., Tolić, N., Grigoriev, I. V., Tsang, A., Mäkelä, M. R., Snel, B., Peng, M., & de Vries, R. P. (2022). The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum. Journal of Fungi, 8(12). https://doi.org/10.3390/jof8121315

@article{71058b3654bc47caa8e73c56be931655,

title = "The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum.",

abstract = "Fungi play a critical role in the global carbon cycle by degrading plant polysaccharides to small sugars and metabolizing them as carbon and energy sources. We mapped the well-established sugar metabolic network of Aspergillus niger to five taxonomically distant species ( Aspergillus nidulans, Penicillium subrubescens, Trichoderma reesei, Phanerochaete chrysosporium and Dichomitus squalens) using an orthology-based approach. The diversity of sugar metabolism correlates well with the taxonomic distance of the fungi. The pathways are highly conserved between the three studied Eurotiomycetes ( A. niger, A. nidulans, P. subrubescens). A higher level of diversity was observed between the T. reesei and A. niger, and even more so for the two Basidiomycetes. These results were confirmed by integrative analysis of transcriptome, proteome and metabolome, as well as growth profiles of the fungi growing on the corresponding sugars. In conclusion, the establishment of sugar pathway models in different fungi revealed the diversity of fungal sugar conversion and provided a valuable resource for the community, which would facilitate rational metabolic engineering of these fungi as microbial cell factories. ",

author = "Jiajia Li and Tania Chroumpi and Sandra Garrigues and Kun, {Roland S} and Jiali Meng and Sonia Salazar-Cerezo and Aguilar-Pontes, {Maria Victoria} and Yu Zhang and Sravanthi Tejomurthula and Anna Lipzen and Vivian Ng and Clendinen, {Chaevien S} and Nikola Toli{\'c} and Grigoriev, {Igor V} and Adrian Tsang and M{\"a}kel{\"a}, {Miia R} and Berend Snel and Mao Peng and {de Vries}, {Ronald P}",

year = "2022",

month = dec,

day = "17",

doi = "10.3390/jof8121315",

language = "English",

volume = "8",

journal = "Journal of Fungi",

issn = "2309-608X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

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Li, J, Chroumpi, T, Garrigues, S, Kun, RS, Meng, J, Salazar-Cerezo, S, Aguilar-Pontes, MV, Zhang, Y, Tejomurthula, S, Lipzen, A, Ng, V, Clendinen, CS, Tolić, N, Grigoriev, IV, Tsang, A, Mäkelä, MR, Snel, B, Peng, M & de Vries, RP 2022, 'The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum.', Journal of Fungi, vol. 8, no. 12. https://doi.org/10.3390/jof8121315

TY - JOUR

T1 - The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum.

AU - Li, Jiajia

AU - Chroumpi, Tania

AU - Garrigues, Sandra

AU - Kun, Roland S

AU - Meng, Jiali

AU - Salazar-Cerezo, Sonia

AU - Aguilar-Pontes, Maria Victoria

AU - Zhang, Yu

AU - Tejomurthula, Sravanthi

AU - Lipzen, Anna

AU - Ng, Vivian

AU - Clendinen, Chaevien S

AU - Tolić, Nikola

AU - Grigoriev, Igor V

AU - Tsang, Adrian

AU - Mäkelä, Miia R

AU - Snel, Berend

AU - Peng, Mao

AU - de Vries, Ronald P

PY - 2022/12/17

Y1 - 2022/12/17

N2 - Fungi play a critical role in the global carbon cycle by degrading plant polysaccharides to small sugars and metabolizing them as carbon and energy sources. We mapped the well-established sugar metabolic network of Aspergillus niger to five taxonomically distant species ( Aspergillus nidulans, Penicillium subrubescens, Trichoderma reesei, Phanerochaete chrysosporium and Dichomitus squalens) using an orthology-based approach. The diversity of sugar metabolism correlates well with the taxonomic distance of the fungi. The pathways are highly conserved between the three studied Eurotiomycetes ( A. niger, A. nidulans, P. subrubescens). A higher level of diversity was observed between the T. reesei and A. niger, and even more so for the two Basidiomycetes. These results were confirmed by integrative analysis of transcriptome, proteome and metabolome, as well as growth profiles of the fungi growing on the corresponding sugars. In conclusion, the establishment of sugar pathway models in different fungi revealed the diversity of fungal sugar conversion and provided a valuable resource for the community, which would facilitate rational metabolic engineering of these fungi as microbial cell factories.

AB - Fungi play a critical role in the global carbon cycle by degrading plant polysaccharides to small sugars and metabolizing them as carbon and energy sources. We mapped the well-established sugar metabolic network of Aspergillus niger to five taxonomically distant species ( Aspergillus nidulans, Penicillium subrubescens, Trichoderma reesei, Phanerochaete chrysosporium and Dichomitus squalens) using an orthology-based approach. The diversity of sugar metabolism correlates well with the taxonomic distance of the fungi. The pathways are highly conserved between the three studied Eurotiomycetes ( A. niger, A. nidulans, P. subrubescens). A higher level of diversity was observed between the T. reesei and A. niger, and even more so for the two Basidiomycetes. These results were confirmed by integrative analysis of transcriptome, proteome and metabolome, as well as growth profiles of the fungi growing on the corresponding sugars. In conclusion, the establishment of sugar pathway models in different fungi revealed the diversity of fungal sugar conversion and provided a valuable resource for the community, which would facilitate rational metabolic engineering of these fungi as microbial cell factories.

U2 - 10.3390/jof8121315

DO - 10.3390/jof8121315

M3 - Article

C2 - 36547648

SN - 2309-608X

VL - 8

JO - Journal of Fungi

JF - Journal of Fungi

IS - 12

ER -

The Sugar Metabolic Model of Aspergillus niger Can Only Be Reliably Transferred to Fungi of Its Phylum.

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