Tissue-specific designs of stem cell hierarchies

TY - JOUR

T1 - Tissue-specific designs of stem cell hierarchies

AU - Visvader, Jane E

AU - Clevers, Hans

PY - 2016/4

Y1 - 2016/4

N2 - Recent work in the field of stem cell biology suggests that there is no single design for an adult tissue stem cell hierarchy, and that different tissues employ distinct strategies to meet their self-renewal and repair requirements. Stem cells may be multipotent or unipotent, and can exist in quiescent or actively dividing states. 'Professional' stem cells may also co-exist with facultative stem cells, which are more specialized daughter cells that revert to a stem cell state under specific tissue damage conditions. Here, we discuss stem cell strategies as seen in three solid mammalian tissues: the intestine, mammary gland and skeletal muscle.

AB - Recent work in the field of stem cell biology suggests that there is no single design for an adult tissue stem cell hierarchy, and that different tissues employ distinct strategies to meet their self-renewal and repair requirements. Stem cells may be multipotent or unipotent, and can exist in quiescent or actively dividing states. 'Professional' stem cells may also co-exist with facultative stem cells, which are more specialized daughter cells that revert to a stem cell state under specific tissue damage conditions. Here, we discuss stem cell strategies as seen in three solid mammalian tissues: the intestine, mammary gland and skeletal muscle.

U2 - 10.1038/ncb3332

DO - 10.1038/ncb3332

M3 - Article

C2 - 26999737

SN - 1465-7392

VL - 18

SP - 349

EP - 355

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 4

ER -