Topology of mammalian developmental enhancers and their regulatory landscapes

TY - JOUR

T1 - Topology of mammalian developmental enhancers and their regulatory landscapes

AU - de Laat, W.

AU - Duboule, D.

N1 - Reporting year: 2013

PY - 2013

Y1 - 2013

N2 - How a complex animal can arise from a fertilized egg is one of the oldest and most fascinating questions of biology, the answer to which is encoded in the genome. Body shape and organ development, and their integration into a functional organism all depend on the precise expression of genes in space and time. The orchestration of transcription relies mostly on surrounding control sequences such as enhancers, millions of which form complex regulatory landscapes in the non-coding genome. Recent research shows that high-order chromosome structures make an important contribution to enhancer functionality by triggering their physical interactions with target genes.

AB - How a complex animal can arise from a fertilized egg is one of the oldest and most fascinating questions of biology, the answer to which is encoded in the genome. Body shape and organ development, and their integration into a functional organism all depend on the precise expression of genes in space and time. The orchestration of transcription relies mostly on surrounding control sequences such as enhancers, millions of which form complex regulatory landscapes in the non-coding genome. Recent research shows that high-order chromosome structures make an important contribution to enhancer functionality by triggering their physical interactions with target genes.

U2 - 10.1038/nature12753

DO - 10.1038/nature12753

M3 - Article

SN - 0028-0836

VL - 502

SP - 499

EP - 506

JO - Nature

JF - Nature

IS - 7472

ER -