Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration

TY - JOUR

T1 - Transcriptional Dynamics at Brain Enhancers

T2 - from Functional Specialization to Neurodegeneration

AU - Vermunt, Marit W

AU - Creyghton, Menno P

PY - 2016

Y1 - 2016

N2 - Over the last decade, the noncoding part of the genome has been shown to harbour thousands of cis-regulatory elements, such as enhancers, that activate well-defined gene expression programs. Driven by the development of numerous techniques, many of these elements are now identified in multiple tissues and cell types, and their characteristics as well as importance in development and disease are becoming increasingly clear. Here, we provide an overview of the insights that were gained from the analysis of noncoding gene regulatory elements in the brain and describe their potential contribution to cell type specialization, brain function and neurodegenerative disease.

AB - Over the last decade, the noncoding part of the genome has been shown to harbour thousands of cis-regulatory elements, such as enhancers, that activate well-defined gene expression programs. Driven by the development of numerous techniques, many of these elements are now identified in multiple tissues and cell types, and their characteristics as well as importance in development and disease are becoming increasingly clear. Here, we provide an overview of the insights that were gained from the analysis of noncoding gene regulatory elements in the brain and describe their potential contribution to cell type specialization, brain function and neurodegenerative disease.

KW - Journal Article

KW - Review

U2 - 10.1007/s11910-016-0689-7

DO - 10.1007/s11910-016-0689-7

M3 - Article

C2 - 27628759

SN - 1528-4042

VL - 16

SP - 94

JO - Current Neurology and Neuroscience Reports

JF - Current Neurology and Neuroscience Reports

IS - 10

ER -