Translation information processing is regulated by protein kinase C-dependent mechanism in Purkinje cells in murine posterior vermis

Rosendo G Hernández; Chris I De Zeeuw; Ruyan Zhang; Tatyana A Yakusheva; Pablo M Blazquez

doi:10.1073/pnas.2002177117

Translation information processing is regulated by protein kinase C-dependent mechanism in Purkinje cells in murine posterior vermis

Rosendo G Hernández, Chris I De Zeeuw, Ruyan Zhang, Tatyana A Yakusheva, Pablo M Blazquez

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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Abstract

The cerebellar posterior vermis generates an estimation of our motion (translation) and orientation (tilt) in space using cues originating from semicircular canals and otolith organs. Theoretical work has laid out the basic computations necessary for this signal transformation, but details on the cellular loci and mechanisms responsible are lacking. Using a multicomponent modeling approach, we show that canal and otolith information are spatially and temporally matched in mouse posterior vermis Purkinje cells and that Purkinje cell responses combine translation and tilt information. Purkinje cell-specific inhibition of protein kinase C decreased and phase-shifted the translation component of Purkinje cell responses, but did not affect the tilt component. Our findings suggest that translation and tilt signals reach Purkinje cells via separate information pathways and that protein kinase C-dependent mechanisms regulate translation information processing in cerebellar cortex output neurons.

Original language	English
Pages (from-to)	17348-17358
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	117
DOIs	https://doi.org/10.1073/pnas.2002177117
Publication status	Published - 2020

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@article{58e204618062456e9fa3139090574dee,

title = "Translation information processing is regulated by protein kinase C-dependent mechanism in Purkinje cells in murine posterior vermis",

abstract = "The cerebellar posterior vermis generates an estimation of our motion (translation) and orientation (tilt) in space using cues originating from semicircular canals and otolith organs. Theoretical work has laid out the basic computations necessary for this signal transformation, but details on the cellular loci and mechanisms responsible are lacking. Using a multicomponent modeling approach, we show that canal and otolith information are spatially and temporally matched in mouse posterior vermis Purkinje cells and that Purkinje cell responses combine translation and tilt information. Purkinje cell-specific inhibition of protein kinase C decreased and phase-shifted the translation component of Purkinje cell responses, but did not affect the tilt component. Our findings suggest that translation and tilt signals reach Purkinje cells via separate information pathways and that protein kinase C-dependent mechanisms regulate translation information processing in cerebellar cortex output neurons.",

author = "Hern{\'a}ndez, {Rosendo G} and {De Zeeuw}, {Chris I} and Ruyan Zhang and Yakusheva, {Tatyana A} and Blazquez, {Pablo M}",

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doi = "10.1073/pnas.2002177117",

language = "English",

volume = "117",

pages = "17348--17358",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

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Translation information processing is regulated by protein kinase C-dependent mechanism in Purkinje cells in murine posterior vermis. / Hernández, Rosendo G; De Zeeuw, Chris I; Zhang, Ruyan; Yakusheva, Tatyana A; Blazquez, Pablo M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, 2020, p. 17348-17358.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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AU - Blazquez, Pablo M

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AB - The cerebellar posterior vermis generates an estimation of our motion (translation) and orientation (tilt) in space using cues originating from semicircular canals and otolith organs. Theoretical work has laid out the basic computations necessary for this signal transformation, but details on the cellular loci and mechanisms responsible are lacking. Using a multicomponent modeling approach, we show that canal and otolith information are spatially and temporally matched in mouse posterior vermis Purkinje cells and that Purkinje cell responses combine translation and tilt information. Purkinje cell-specific inhibition of protein kinase C decreased and phase-shifted the translation component of Purkinje cell responses, but did not affect the tilt component. Our findings suggest that translation and tilt signals reach Purkinje cells via separate information pathways and that protein kinase C-dependent mechanisms regulate translation information processing in cerebellar cortex output neurons.

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