Translational applications of adult stem cell-derived organoids

Jarno Drost, Hans Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.

Original languageEnglish
Pages (from-to)968-975
Number of pages8
JournalDevelopment (Cambridge)
Volume144
Issue number6
DOIs
Publication statusPublished - 15 Mar 2017

Keywords

  • Adult
  • Adult Stem Cells
  • Humans
  • Neoplasms
  • Organoids
  • Precision Medicine
  • Regenerative Medicine
  • Translational Medical Research
  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't

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