Tuberculosis/cryptococcosis co-infection in China between 1965 and 2016

Wenjie Fang, Lei Zhang, Jia Liu, David W Denning, Ferry Hagen, Wei-Wei Jiang, Nan Hong, Shuwen Deng, Xia Lei, Danqi Deng, Wanqing Liao, Jianping Xu, Teun Boekhout, Min Chen, Weihua Pan

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Cases of tuberculosis/cryptococcosis co-infection are rapidly increasing in China. However, most studies addressing this co-infection have been published in Chinese journals, and this publication strategy has obscured this disease trend for scientists in other parts of the world. Our investigation found that 62.9% of all co-infection cases worldwide were reported in the Chinese population (n=197) between 1965 and 2016, and 56.3% of these Chinese cases were reported after 2010. Nearly all cases originated from the warm and wet monsoon regions of China. HIV-positive subjects tended to correlate with more severe manifestations of a tuberculosis/cryptococcosis co-infection than those without HIV. Notablely, dual tubercular/cryptococcal meningitis was the most frequent (54.0 and most easily misdiagnosed (95.2 n=40/42) co-infection. We also found that the combined use of cerebrospinal fluid pressure and concentrations of glucose, protein and chlorine might be an inexpensive and effective indicator to differentiate tubercular/cryptococcal co-infection meningitis from tubercular meningitis and cryptococcal meningitis.
Original languageEnglish
Pages (from-to)e73
JournalEmerging Microbes and Infections
Volume6
DOIs
Publication statusPublished - 01 Aug 2017

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