Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Zebrafish are increasingly being used to study cancer. Almost all tumor types have been found in zebrafish. However, tumor incidence is relatively low and tumors develop late in life. Functional inactivation of tumor suppressors is a crucial step in cancer progression and more and more tumor suppressor genes are being studied in zebrafish. Most often tumor suppressors have been inactivated by reverse genetics approaches using targeted disruption. However, some tumor suppressor mutants were identified by forward genetic screens for mutants with a particular phenotype. Some of the latter genes had not been recognized as tumor suppressors yet. Similarly, a screen for genes that suppress tumor formation in zebrafish in vivo led to the identification of a novel tumor suppressor gene. In this review, I will provide an overview of what the zebrafish has taught us about tumor suppressors.

Original languageEnglish
Pages (from-to)87-101
Number of pages15
JournalAdvances in Experimental Medicine and Biology
Volume916
DOIs
Publication statusPublished - 2016

Fingerprint

Dive into the research topics of 'Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond'. Together they form a unique fingerprint.

Cite this