Ultra-high field fMRI reveals origins of feedforward and feedback activity within laminae of human ocular dominance columns

Gilles de Hollander; Wietske van der Zwaag; Chencan Qian; Peng Zhang; Tomas Knapen

doi:10.1016/j.neuroimage.2020.117683

Ultra-high field fMRI reveals origins of feedforward and feedback activity within laminae of human ocular dominance columns

Gilles de Hollander, Wietske van der Zwaag, Chencan Qian, Peng Zhang, Tomas Knapen

Spinoza Centre for Neuroimaging

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

163 Downloads (Pure)

Abstract

Ultra-high field MRI can functionally image the cerebral cortex of human subjects at the submillimeter scale of cortical columns and laminae. Here, we investigate both in concert, by imaging ocular dominance columns (ODCs) in primary visual cortex (V1) across different cortical depths. We ensured that putative ODC patterns in V1 (a) are stable across runs, sessions, and scanners located in different continents, (b) have a width (∼1.3 mm) expected from post-mortem and animal work and (c) are absent at the retinotopic location of the blind spot. We then dissociated the effects of bottom-up thalamo-cortical input and attentional feedback processes on activity in V1 across cortical depth. Importantly, the separation of bottom-up information flows into ODCs allowed us to validly compare attentional conditions while keeping the stimulus identical throughout the experiment. We find that, when correcting for draining vein effects and using both model-based and model-free approaches, the effect of monocular stimulation is largest at deep and middle cortical depths. Conversely, spatial attention influences BOLD activity exclusively near the pial surface. Our findings show that simultaneous interrogation of columnar and laminar dimensions of the cortical fold can dissociate thalamocortical inputs from top-down processing, and allow the investigation of their interactions without any stimulus manipulation.

Original language	English
Pages (from-to)	117683
Journal	NeuroImage
Volume	228
DOIs	https://doi.org/10.1016/j.neuroimage.2020.117683
Publication status	Published - 2021

Access to Document

10.1016/j.neuroimage.2020.117683

Hollander2021Final published version, 2.45 MBLicence: CC BY

Cite this

@article{813744ab35ca4e24ae8efc1863fc513e,

title = "Ultra-high field fMRI reveals origins of feedforward and feedback activity within laminae of human ocular dominance columns",

abstract = "Ultra-high field MRI can functionally image the cerebral cortex of human subjects at the submillimeter scale of cortical columns and laminae. Here, we investigate both in concert, by imaging ocular dominance columns (ODCs) in primary visual cortex (V1) across different cortical depths. We ensured that putative ODC patterns in V1 (a) are stable across runs, sessions, and scanners located in different continents, (b) have a width (∼1.3 mm) expected from post-mortem and animal work and (c) are absent at the retinotopic location of the blind spot. We then dissociated the effects of bottom-up thalamo-cortical input and attentional feedback processes on activity in V1 across cortical depth. Importantly, the separation of bottom-up information flows into ODCs allowed us to validly compare attentional conditions while keeping the stimulus identical throughout the experiment. We find that, when correcting for draining vein effects and using both model-based and model-free approaches, the effect of monocular stimulation is largest at deep and middle cortical depths. Conversely, spatial attention influences BOLD activity exclusively near the pial surface. Our findings show that simultaneous interrogation of columnar and laminar dimensions of the cortical fold can dissociate thalamocortical inputs from top-down processing, and allow the investigation of their interactions without any stimulus manipulation.",

author = "{de Hollander}, Gilles and {van der Zwaag}, Wietske and Chencan Qian and Peng Zhang and Tomas Knapen",

year = "2021",

doi = "10.1016/j.neuroimage.2020.117683",

language = "English",

volume = "228",

pages = "117683",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Academic Press",

}

TY - JOUR

T1 - Ultra-high field fMRI reveals origins of feedforward and feedback activity within laminae of human ocular dominance columns

AU - de Hollander, Gilles

AU - van der Zwaag, Wietske

AU - Qian, Chencan

AU - Zhang, Peng

AU - Knapen, Tomas

PY - 2021

Y1 - 2021

N2 - Ultra-high field MRI can functionally image the cerebral cortex of human subjects at the submillimeter scale of cortical columns and laminae. Here, we investigate both in concert, by imaging ocular dominance columns (ODCs) in primary visual cortex (V1) across different cortical depths. We ensured that putative ODC patterns in V1 (a) are stable across runs, sessions, and scanners located in different continents, (b) have a width (∼1.3 mm) expected from post-mortem and animal work and (c) are absent at the retinotopic location of the blind spot. We then dissociated the effects of bottom-up thalamo-cortical input and attentional feedback processes on activity in V1 across cortical depth. Importantly, the separation of bottom-up information flows into ODCs allowed us to validly compare attentional conditions while keeping the stimulus identical throughout the experiment. We find that, when correcting for draining vein effects and using both model-based and model-free approaches, the effect of monocular stimulation is largest at deep and middle cortical depths. Conversely, spatial attention influences BOLD activity exclusively near the pial surface. Our findings show that simultaneous interrogation of columnar and laminar dimensions of the cortical fold can dissociate thalamocortical inputs from top-down processing, and allow the investigation of their interactions without any stimulus manipulation.

AB - Ultra-high field MRI can functionally image the cerebral cortex of human subjects at the submillimeter scale of cortical columns and laminae. Here, we investigate both in concert, by imaging ocular dominance columns (ODCs) in primary visual cortex (V1) across different cortical depths. We ensured that putative ODC patterns in V1 (a) are stable across runs, sessions, and scanners located in different continents, (b) have a width (∼1.3 mm) expected from post-mortem and animal work and (c) are absent at the retinotopic location of the blind spot. We then dissociated the effects of bottom-up thalamo-cortical input and attentional feedback processes on activity in V1 across cortical depth. Importantly, the separation of bottom-up information flows into ODCs allowed us to validly compare attentional conditions while keeping the stimulus identical throughout the experiment. We find that, when correcting for draining vein effects and using both model-based and model-free approaches, the effect of monocular stimulation is largest at deep and middle cortical depths. Conversely, spatial attention influences BOLD activity exclusively near the pial surface. Our findings show that simultaneous interrogation of columnar and laminar dimensions of the cortical fold can dissociate thalamocortical inputs from top-down processing, and allow the investigation of their interactions without any stimulus manipulation.

U2 - 10.1016/j.neuroimage.2020.117683

DO - 10.1016/j.neuroimage.2020.117683

M3 - Article

C2 - 33385565

VL - 228

SP - 117683

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -

Ultra-high field fMRI reveals origins of feedforward and feedback activity within laminae of human ocular dominance columns

Abstract

Access to Document

Fingerprint

Cite this