Unconventional secretion: a stress on GRASP

F. Giuliani; A. Grieve; C. Rabouille

doi:10.1016/j.ceb.2011.04.005

Unconventional secretion: a stress on GRASP

F. Giuliani, A. Grieve, C. Rabouille

Hubrecht Institute

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Abstract

Most proteins follow the classical secretory pathway from the endoplasmic reticulum, via the Golgi, to the plasma membrane or extracellular medium. However, some proteins reach these final destinations by two alternative routes. One sustains the extracellular delivery of cytoplasmic proteins that lack a signal peptide, the other supports the transport of transmembrane proteins to the plasma membrane in a manner that bypasses the Golgi. Here, we highlight the observation that some unconventional secretion events are triggered by cellular stress. Furthermore, one Golgi protein, Golgi Re-Assembly and Stacking Protein (GRASP), has been shown to be essential to both types of unconventional secretion and we discuss ways in which it may support these events in a Golgi-independent manner. [KEYWORDS: Animals, Cell Membrane/metabolism, Endoplasmic Reticulum/metabolism, Golgi Apparatus/metabolism, Humans, Membrane Proteins/ metabolism, Secretory Pathway, Yeasts/cytology/metabolism]

Original language	English
Pages (from-to)	498-504
Journal	Current Opinion in Cell Biology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.ceb.2011.04.005
Publication status	Published - 2011

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title = "Unconventional secretion: a stress on GRASP",

abstract = "Most proteins follow the classical secretory pathway from the endoplasmic reticulum, via the Golgi, to the plasma membrane or extracellular medium. However, some proteins reach these final destinations by two alternative routes. One sustains the extracellular delivery of cytoplasmic proteins that lack a signal peptide, the other supports the transport of transmembrane proteins to the plasma membrane in a manner that bypasses the Golgi. Here, we highlight the observation that some unconventional secretion events are triggered by cellular stress. Furthermore, one Golgi protein, Golgi Re-Assembly and Stacking Protein (GRASP), has been shown to be essential to both types of unconventional secretion and we discuss ways in which it may support these events in a Golgi-independent manner. [KEYWORDS: Animals, Cell Membrane/metabolism, Endoplasmic Reticulum/metabolism, Golgi Apparatus/metabolism, Humans, Membrane Proteins/ metabolism, Secretory Pathway, Yeasts/cytology/metabolism]",

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T1 - Unconventional secretion: a stress on GRASP

AU - Giuliani, F.

AU - Grieve, A.

AU - Rabouille, C.

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PY - 2011

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N2 - Most proteins follow the classical secretory pathway from the endoplasmic reticulum, via the Golgi, to the plasma membrane or extracellular medium. However, some proteins reach these final destinations by two alternative routes. One sustains the extracellular delivery of cytoplasmic proteins that lack a signal peptide, the other supports the transport of transmembrane proteins to the plasma membrane in a manner that bypasses the Golgi. Here, we highlight the observation that some unconventional secretion events are triggered by cellular stress. Furthermore, one Golgi protein, Golgi Re-Assembly and Stacking Protein (GRASP), has been shown to be essential to both types of unconventional secretion and we discuss ways in which it may support these events in a Golgi-independent manner. [KEYWORDS: Animals, Cell Membrane/metabolism, Endoplasmic Reticulum/metabolism, Golgi Apparatus/metabolism, Humans, Membrane Proteins/ metabolism, Secretory Pathway, Yeasts/cytology/metabolism]

AB - Most proteins follow the classical secretory pathway from the endoplasmic reticulum, via the Golgi, to the plasma membrane or extracellular medium. However, some proteins reach these final destinations by two alternative routes. One sustains the extracellular delivery of cytoplasmic proteins that lack a signal peptide, the other supports the transport of transmembrane proteins to the plasma membrane in a manner that bypasses the Golgi. Here, we highlight the observation that some unconventional secretion events are triggered by cellular stress. Furthermore, one Golgi protein, Golgi Re-Assembly and Stacking Protein (GRASP), has been shown to be essential to both types of unconventional secretion and we discuss ways in which it may support these events in a Golgi-independent manner. [KEYWORDS: Animals, Cell Membrane/metabolism, Endoplasmic Reticulum/metabolism, Golgi Apparatus/metabolism, Humans, Membrane Proteins/ metabolism, Secretory Pathway, Yeasts/cytology/metabolism]

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DO - 10.1016/j.ceb.2011.04.005

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VL - 23

SP - 498

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JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

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ER -

Unconventional secretion: a stress on GRASP

Abstract

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