Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii

M. Bovers; F. Hagen; E.E. Kuramae; M.R. Diaz; L. Spanjaard; F. Dromer; H.L. Hoogveld; T. Boekhout

doi:10.1111/j.1567-1364.2006.00082.x

Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii

M. Bovers, F. Hagen, E.E. Kuramae, M.R. Diaz, L. Spanjaard, F. Dromer, H.L. Hoogveld, T. Boekhout

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

115 Citations (Scopus)

Abstract

Cryptococcus neoformans and Cryptococcus gattii are yeasts that cause meningoencephalitis, but that differ in host range and geographical distribution. Cryptococcus neoformans occurs world-wide and mostly infects immunocompromised patients, whereas C. gattii occurs mainly in (sub)tropical regions and infects healthy individuals. Anomalous C. neoformans strains were isolated from patients. These strains were found to be monokaryotic, and diploid or aneuploid. Amplified Fragment Length Polymorphism (AFLP) and sequence analyses indicated that AFLP genotypes 2 (C. neoformans) and 4 (C. gattii) were present. The strains were serologically BD. Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MATa-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii. [KEYWORDS: Cryptococcus neoformans ; Cryptococcus gattii ; BD hybrid ; recurrent meningitis]

Original language	English
Pages (from-to)	599-607
Journal	FEMS Yeast Research
Volume	6
Issue number	4
DOIs	https://doi.org/10.1111/j.1567-1364.2006.00082.x
Publication status	Published - 2006

Access to Document

10.1111/j.1567-1364.2006.00082.x

Embargoed Document

PDF
Final published version, 863 KB

Cite this

@article{8a3baeadbc0048b6bf5b20c3d1aa4512,

title = "Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii",

abstract = "Cryptococcus neoformans and Cryptococcus gattii are yeasts that cause meningoencephalitis, but that differ in host range and geographical distribution. Cryptococcus neoformans occurs world-wide and mostly infects immunocompromised patients, whereas C. gattii occurs mainly in (sub)tropical regions and infects healthy individuals. Anomalous C. neoformans strains were isolated from patients. These strains were found to be monokaryotic, and diploid or aneuploid. Amplified Fragment Length Polymorphism (AFLP) and sequence analyses indicated that AFLP genotypes 2 (C. neoformans) and 4 (C. gattii) were present. The strains were serologically BD. Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MATa-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii. [KEYWORDS: Cryptococcus neoformans ; Cryptococcus gattii ; BD hybrid ; recurrent meningitis]",

author = "M. Bovers and F. Hagen and E.E. Kuramae and M.R. Diaz and L. Spanjaard and F. Dromer and H.L. Hoogveld and T. Boekhout",

note = "Reporting year: 2006 Metis note: 3863;CL; file:///L:/Endnotedatabases/NIOOPUB/pdfs/Pdfs2006/Bovers_ea_3863.pdf",

year = "2006",

doi = "10.1111/j.1567-1364.2006.00082.x",

language = "English",

volume = "6",

pages = "599--607",

journal = "FEMS Yeast Research",

issn = "1567-1356",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii

AU - Bovers, M.

AU - Hagen, F.

AU - Kuramae, E.E.

AU - Diaz, M.R.

AU - Spanjaard, L.

AU - Dromer, F.

AU - Hoogveld, H.L.

AU - Boekhout, T.

N1 - Reporting year: 2006 Metis note: 3863;CL; file:///L:/Endnotedatabases/NIOOPUB/pdfs/Pdfs2006/Bovers_ea_3863.pdf

PY - 2006

Y1 - 2006

N2 - Cryptococcus neoformans and Cryptococcus gattii are yeasts that cause meningoencephalitis, but that differ in host range and geographical distribution. Cryptococcus neoformans occurs world-wide and mostly infects immunocompromised patients, whereas C. gattii occurs mainly in (sub)tropical regions and infects healthy individuals. Anomalous C. neoformans strains were isolated from patients. These strains were found to be monokaryotic, and diploid or aneuploid. Amplified Fragment Length Polymorphism (AFLP) and sequence analyses indicated that AFLP genotypes 2 (C. neoformans) and 4 (C. gattii) were present. The strains were serologically BD. Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MATa-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii. [KEYWORDS: Cryptococcus neoformans ; Cryptococcus gattii ; BD hybrid ; recurrent meningitis]

AB - Cryptococcus neoformans and Cryptococcus gattii are yeasts that cause meningoencephalitis, but that differ in host range and geographical distribution. Cryptococcus neoformans occurs world-wide and mostly infects immunocompromised patients, whereas C. gattii occurs mainly in (sub)tropical regions and infects healthy individuals. Anomalous C. neoformans strains were isolated from patients. These strains were found to be monokaryotic, and diploid or aneuploid. Amplified Fragment Length Polymorphism (AFLP) and sequence analyses indicated that AFLP genotypes 2 (C. neoformans) and 4 (C. gattii) were present. The strains were serologically BD. Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MATa-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii. [KEYWORDS: Cryptococcus neoformans ; Cryptococcus gattii ; BD hybrid ; recurrent meningitis]

U2 - 10.1111/j.1567-1364.2006.00082.x

DO - 10.1111/j.1567-1364.2006.00082.x

M3 - Article

SN - 1567-1356

VL - 6

SP - 599

EP - 607

JO - FEMS Yeast Research

JF - FEMS Yeast Research

IS - 4

ER -

Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii

Abstract

Access to Document

Embargoed Document

Fingerprint

Cite this