Use and application of 3D-organoid technology

Benedetta Artegiani, Hans Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

The capacity of the 3D-organoid cultures to resemble a near-physiological tissue organization and to mimic - to a certain degree - organ functionality, make organoids an excellent model for applications spanning from basic developmental/stem cell research to personalized medicine. Here, we review key findings achieved through organoid technology, and we discuss applications such as disease - and tumour modelling, correction of genetic mutations and understanding gene - and cell functions. Finally, we discuss future developments in the field.

Original languageEnglish
Pages (from-to)R99-R107
JournalHuman Molecular Genetics
Volume27
Issue numberR2
DOIs
Publication statusPublished - 01 Aug 2018

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