• J. Laoukili
  • M.R.H. Kooistra
  • A. Bras
  • J. Kauw
  • R.M. Kerkhoven
  • A. Morrison
  • J.C. Clevers
  • R.H. Medema
Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 regulates expression of many G2-specific genes and is essential for chromosome stability. Loss of FoxM1 leads to pleiotropic cell-cycle defects, including a delay in G2, chromosome mis-segregation and frequent failure of cytokinesis. We show that transcriptional activation of cyclin B by FoxM1 is essential for timely mitotic entry, whereas CENP-F, another direct target of FoxM1 identified here, is essential for precise functioning of the mitotic spindle checkpoint. Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression.
Original languageEnglish
JournalNature Cell Biology
Journal publication date2005

ID: 446094