• D.D.G. Despriet
  • C.C.W. Klaver
  • J.C.M. Witteman
  • A.A.B. Bergen
  • I. Kardys
  • M.P.M. de Maat
  • S.S. Boekhoorn
  • J.R. Vingerling
  • A. Hofman
  • B.A. Oostra
  • A.G. Uitterlinden
  • Th. Stijnen
  • C.M. van Duijn
  • P.T.V.M. de Jong
Context: The evidence that inflammation is an important pathway in age-related macular degeneration (AMD) is growing. Recent case-control studies demonstrated an association between the complement factor H (CFH) gene, a regulator of complement, and AMD. Objectives: To assess the associations between the CFH gene and AMD in the general population and to investigate the modifying effect of smoking, serum inflammatory markers, and genetic variation of C-reactive protein (CRP). Design, Setting, and Participants: Population-based, prospective cohort study of individuals aged 55 years or older (enrollment between March 20, 1990, and July 31, 1993, and 3 follow-up examinations that were performed between September 1, 1993, and December 31, 2004) in Rotterdam, the Netherlands. The CFH Y402H polymorphism was determined in a total of 5681 individuals. Information on smoking, erythrocyte sedimentation rate, CRP serum levels, and haplotypes of the CRP gene were assessed at baseline. Main Outcome Measures: All severity stages of prevalent and incident AMD, graded according to the international classification and grading system for AMD.
Original languageEnglish
Journal publication date2006

ID: 440386