Vertebrate Endothermy Restricts Most Fungi as Potential Pathogens

V.A.R.G. Robert, A. Casadevall

    Research output: Contribution to journal/periodicalArticleScientificpeer-review


    The paucity of fungal diseases in mammals relative to insects, amphibians, and plants is puzzling. We analyzed the thermal tolerance of 4802 fungal strains from 144 genera and found that most cannot grow at mammalian temperatures. Fungi from insects and mammals had greater thermal tolerances than did isolates from soils and plants. Every 1 degrees C increase in the 30 degrees C-40 degrees C range excluded an additional 6% of fungal isolates, implying that fever could significantly increase the thermal exclusion zone. Mammalian endothermy and homeothermy are potent nonspecific defenses against most fungi that could have provided a strong evolutionary survival advantage against fungal diseases.
    Original languageEnglish
    Pages (from-to)1623-1626
    JournalJournal of Infectious Diseases
    Issue number10
    Publication statusPublished - 2009


    Dive into the research topics of 'Vertebrate Endothermy Restricts Most Fungi as Potential Pathogens'. Together they form a unique fingerprint.

    Cite this