Virulence markers of opportunistic black yeast in Exophiala

Hafize Sav; Fatma Ozakkas; Rabiye Altınbas; Nuri Kiraz; Ayşegül Tümgör; Ramazan Gümral; Aylin Döğen; Macit Ilkit; G Sybren de Hoog

doi:10.1111/myc.12478

Virulence markers of opportunistic black yeast in Exophiala

Hafize Sav, Fatma Ozakkas, Rabiye Altınbas, Nuri Kiraz, Ayşegül Tümgör, Ramazan Gümral, Aylin Döğen, Macit Ilkit, G Sybren de Hoog

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

The black yeast genus Exophiala is known to cause a wide variety of diseases in severely ill individuals but can also affect immunocompetent individuals. Virulence markers and other physiological parameters were tested in eight clinical and 218 environmental strains, with a specific focus on human-dominated habitats for the latter. Urease and catalase were consistently present in all samples; four strains expressed proteinase and three strains expressed DNase, whereas none of the strains showed phospholipase, haemolysis, or co-haemolysis activities. Biofilm formation was identified in 30 (13.8%) of the environmental isolates, particularly in strains from dishwashers, and was noted in only two (25%) of the clinical strains. These results indicate that virulence factors are inconsistently present in the investigated Exophiala species, suggesting opportunism rather than pathogenicity.

Original language	English
Pages (from-to)	343-50
Number of pages	8
Journal	Mycoses
Volume	59
Issue number	6
DOIs	https://doi.org/10.1111/myc.12478
Publication status	Published - Jun 2016

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title = "Virulence markers of opportunistic black yeast in Exophiala",

abstract = "The black yeast genus Exophiala is known to cause a wide variety of diseases in severely ill individuals but can also affect immunocompetent individuals. Virulence markers and other physiological parameters were tested in eight clinical and 218 environmental strains, with a specific focus on human-dominated habitats for the latter. Urease and catalase were consistently present in all samples; four strains expressed proteinase and three strains expressed DNase, whereas none of the strains showed phospholipase, haemolysis, or co-haemolysis activities. Biofilm formation was identified in 30 (13.8%) of the environmental isolates, particularly in strains from dishwashers, and was noted in only two (25%) of the clinical strains. These results indicate that virulence factors are inconsistently present in the investigated Exophiala species, suggesting opportunism rather than pathogenicity.",

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year = "2016",

month = jun,

doi = "10.1111/myc.12478",

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TY - JOUR

T1 - Virulence markers of opportunistic black yeast in Exophiala

AU - Sav, Hafize

AU - Ozakkas, Fatma

AU - Altınbas, Rabiye

AU - Kiraz, Nuri

AU - Tümgör, Ayşegül

AU - Gümral, Ramazan

AU - Döğen, Aylin

AU - Ilkit, Macit

AU - de Hoog, G Sybren

PY - 2016/6

Y1 - 2016/6

N2 - The black yeast genus Exophiala is known to cause a wide variety of diseases in severely ill individuals but can also affect immunocompetent individuals. Virulence markers and other physiological parameters were tested in eight clinical and 218 environmental strains, with a specific focus on human-dominated habitats for the latter. Urease and catalase were consistently present in all samples; four strains expressed proteinase and three strains expressed DNase, whereas none of the strains showed phospholipase, haemolysis, or co-haemolysis activities. Biofilm formation was identified in 30 (13.8%) of the environmental isolates, particularly in strains from dishwashers, and was noted in only two (25%) of the clinical strains. These results indicate that virulence factors are inconsistently present in the investigated Exophiala species, suggesting opportunism rather than pathogenicity.

AB - The black yeast genus Exophiala is known to cause a wide variety of diseases in severely ill individuals but can also affect immunocompetent individuals. Virulence markers and other physiological parameters were tested in eight clinical and 218 environmental strains, with a specific focus on human-dominated habitats for the latter. Urease and catalase were consistently present in all samples; four strains expressed proteinase and three strains expressed DNase, whereas none of the strains showed phospholipase, haemolysis, or co-haemolysis activities. Biofilm formation was identified in 30 (13.8%) of the environmental isolates, particularly in strains from dishwashers, and was noted in only two (25%) of the clinical strains. These results indicate that virulence factors are inconsistently present in the investigated Exophiala species, suggesting opportunism rather than pathogenicity.

U2 - 10.1111/myc.12478

DO - 10.1111/myc.12478

M3 - Article

C2 - 26857806

SN - 0933-7407

VL - 59

SP - 343

EP - 350

JO - Mycoses

JF - Mycoses

IS - 6

ER -

Virulence markers of opportunistic black yeast in Exophiala

Abstract

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