Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding

Jarno Drost, Hans Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Intratumor heterogeneity is thought to be the driving force of tumor evolution and therapy resistance. Yet tools to study these processes are limited. In this issue, Guernet et al. (2016) devised clustered regularly interspaced short palindromic repeats (CRISPR)-barcoding to functionally annotate specific mutations and study clonal evolution in heterogeneous cell populations.

Original languageEnglish
Pages (from-to)352-4
Number of pages3
JournalMolecular Cell
Volume63
Issue number3
DOIs
Publication statusPublished - 04 Aug 2016

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