Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Roel Nusse; Hans Clevers

doi:10.1016/j.cell.2017.05.016

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Roel Nusse, Hans Clevers

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

3283 Citations (Scopus)

Abstract

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

Original language	English
Pages (from-to)	985-999
Number of pages	15
Journal	Cell
Volume	169
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2017.05.016
Publication status	Published - 01 Jun 2017

Keywords

Animals
Congenital Abnormalities
Humans
Molecular Targeted Therapy
Neoplasms
Organoids
Stem Cells
Wnt Proteins
Wnt Signaling Pathway
Journal Article
Review

Access to Document

10.1016/j.cell.2017.05.016

Cite this

@article{bde52fbbd786461daa920e71cdaa87f2,

title = "Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities",

abstract = "The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.",

keywords = "Animals, Congenital Abnormalities, Humans, Molecular Targeted Therapy, Neoplasms, Organoids, Stem Cells, Wnt Proteins, Wnt Signaling Pathway, Journal Article, Review",

author = "Roel Nusse and Hans Clevers",

year = "2017",

month = jun,

day = "1",

doi = "10.1016/j.cell.2017.05.016",

language = "English",

volume = "169",

pages = "985--999",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

AU - Nusse, Roel

AU - Clevers, Hans

PY - 2017/6/1

Y1 - 2017/6/1

N2 - The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

AB - The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

KW - Animals

KW - Congenital Abnormalities

KW - Humans

KW - Molecular Targeted Therapy

KW - Neoplasms

KW - Organoids

KW - Stem Cells

KW - Wnt Proteins

KW - Wnt Signaling Pathway

KW - Journal Article

KW - Review

U2 - 10.1016/j.cell.2017.05.016

DO - 10.1016/j.cell.2017.05.016

M3 - Article

C2 - 28575679

SN - 0092-8674

VL - 169

SP - 985

EP - 999

JO - Cell

JF - Cell

IS - 6

ER -

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Abstract

Keywords

Access to Document

Fingerprint

Cite this