Wnt/β-catenin signaling in adult mammalian epithelial stem cells

Kai Kretzschmar; Hans Clevers

doi:10.1016/j.ydbio.2017.05.015

Wnt/β-catenin signaling in adult mammalian epithelial stem cells

Kai Kretzschmar, Hans Clevers

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

115 Citations (Scopus)

Abstract

Adult stem cells self-renew and replenish differentiated cells in various organs and tissues throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has unraveled the essential regulation of adult mammalian epithelia by the canonical Wnt signaling with its key intracellular effector β-catenin. In this review, we discuss the principles of the signaling pathway and its role in adult epithelial stem cells of the intestine and skin during homeostasis and tumorigenesis. We further highlight the research that led to the identification of new stem cell markers and methods to study adult stem cells ex vivo.

Original language	English
Pages (from-to)	273-282
Number of pages	10
Journal	Developmental Biology
Volume	428
Issue number	2
DOIs	https://doi.org/10.1016/j.ydbio.2017.05.015
Publication status	Published - 15 Aug 2017

Keywords

Adult Stem Cells
Animals
Cell Self Renewal
Epidermis
Epithelial Cells
Humans
Intestinal Mucosa
Models, Biological
Wnt Signaling Pathway
beta Catenin
Journal Article
Review
Research Support, Non-U.S. Gov't

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title = "Wnt/β-catenin signaling in adult mammalian epithelial stem cells",

abstract = "Adult stem cells self-renew and replenish differentiated cells in various organs and tissues throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has unraveled the essential regulation of adult mammalian epithelia by the canonical Wnt signaling with its key intracellular effector β-catenin. In this review, we discuss the principles of the signaling pathway and its role in adult epithelial stem cells of the intestine and skin during homeostasis and tumorigenesis. We further highlight the research that led to the identification of new stem cell markers and methods to study adult stem cells ex vivo.",

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author = "Kai Kretzschmar and Hans Clevers",

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doi = "10.1016/j.ydbio.2017.05.015",

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AU - Clevers, Hans

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AB - Adult stem cells self-renew and replenish differentiated cells in various organs and tissues throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has unraveled the essential regulation of adult mammalian epithelia by the canonical Wnt signaling with its key intracellular effector β-catenin. In this review, we discuss the principles of the signaling pathway and its role in adult epithelial stem cells of the intestine and skin during homeostasis and tumorigenesis. We further highlight the research that led to the identification of new stem cell markers and methods to study adult stem cells ex vivo.

KW - Adult Stem Cells

KW - Animals

KW - Cell Self Renewal

KW - Epidermis

KW - Epithelial Cells

KW - Humans

KW - Intestinal Mucosa

KW - Models, Biological

KW - Wnt Signaling Pathway

KW - beta Catenin

KW - Journal Article

KW - Review

KW - Research Support, Non-U.S. Gov't

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DO - 10.1016/j.ydbio.2017.05.015

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C2 - 28526587

SN - 0012-1606

VL - 428

SP - 273

EP - 282

JO - Developmental Biology

JF - Developmental Biology

IS - 2

ER -

Wnt/β-catenin signaling in adult mammalian epithelial stem cells

Abstract

Keywords

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