Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

TY - JOUR

T1 - Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

AU - Verhoeven, M.C.

AU - Haase, C.

AU - Christoffels, V.M.

AU - Weidinger, G.

AU - Bakkers, J.

N1 - Reporting year: 2011

PY - 2011

Y1 - 2011

N2 - In the developing heart, the atrioventricular canal (AVC) is essential for separation and alignment of the cardiac chambers, for valve formation, and serves to delay the electrical impulse from the atria to the ventricles. Defects in various aspects of its formation are the most common form of congenital heart defects. Using mutant and transgenic approaches in zebrafish, this study demonstrates that Wnt/beta-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC and consequently the proper patterning of the myocardium. Furthermore, genetic analysis shows that Wnt/beta-catenin signaling is upstream and in a linear pathway with BMP and Tbx2 during AVC specification.

AB - In the developing heart, the atrioventricular canal (AVC) is essential for separation and alignment of the cardiac chambers, for valve formation, and serves to delay the electrical impulse from the atria to the ventricles. Defects in various aspects of its formation are the most common form of congenital heart defects. Using mutant and transgenic approaches in zebrafish, this study demonstrates that Wnt/beta-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC and consequently the proper patterning of the myocardium. Furthermore, genetic analysis shows that Wnt/beta-catenin signaling is upstream and in a linear pathway with BMP and Tbx2 during AVC specification.

U2 - 10.1002/bdra.20804

DO - 10.1002/bdra.20804

M3 - Article

SN - 1542-975X

VL - 91

SP - 435

EP - 440

JO - Birth Defects Research Part C - Embryo Today: Reviews

JF - Birth Defects Research Part C - Embryo Today: Reviews

IS - 6

ER -