Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells.

P.T. Yang, M.J. Lorenowicz, M. Silhankova, D.Y.M. Coudreuse, M.C. Betist, H.C. Korswagen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Wnt proteins are secreted signaling molecules that play a central role in development and adult tissue homeostasis. We have previously shown that Wnt signaling requires retromer function in Wnt-producing cells. The retromer is a multiprotein complex that mediates endosome-to-Golgi transport of specific sorting receptors. MIG-14/Wls is a conserved transmembrane protein that binds Wnt and is required in Wnt-producing cells for Wnt secretion. Here, we demonstrate that in the absence of retromer function, MIG-14/Wls is degraded in lysosomes and becomes limiting for Wnt signaling. We show that retromer-dependent recycling of MIG-14/Wls is part of a trafficking pathway that retrieves MIG-14/Wls from the plasma membrane. We propose that MIG-14/Wls cycles between the Golgi and the plasma membrane to mediate Wnt secretion. Regulation of this transport pathway may enable Wnt-producing cells to control the range of Wnt signaling in the tissue.
Original languageEnglish
Pages (from-to)140-147
JournalDevelopmental Cell
Volume14
Issue number1
DOIs
Publication statusPublished - 2008

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