WNT signalling and haematopoiesis: a WNT-WNT situation.

TY - JOUR

T1 - WNT signalling and haematopoiesis: a WNT-WNT situation.

AU - Staal, F.J.T.

AU - Clevers, J.C.

N1 - doi: 10.1038/nri1529

PY - 2005

Y1 - 2005

N2 - The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

AB - The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

M3 - Article

SN - 1474-1733

VL - 5

SP - 21

EP - 30

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

ER -