Wnt/beta-catenin signaling and disease

H. Clevers, R. Nusse

Research output: Contribution to journal/periodicalArticleScientificpeer-review

4041 Citations (Scopus)


The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/beta-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
Original languageEnglish
Pages (from-to)1192-1205
Issue number6
Publication statusPublished - 2012


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