Wnt/beta-catenin signaling and disease

H. Clevers; R. Nusse

doi:10.1016/j.cell.2012.05.012

Wnt/beta-catenin signaling and disease

H. Clevers, R. Nusse

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

4513 Citations (Scopus)

Abstract

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/beta-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

Original language	English
Pages (from-to)	1192-1205
Journal	Cell
Volume	149
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2012.05.012
Publication status	Published - 2012

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10.1016/j.cell.2012.05.012

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abstract = "The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/beta-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.",

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AB - The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/beta-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

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Wnt/beta-catenin signaling and disease

Abstract

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