Xylitol production from plant biomass by Aspergillus niger through metabolic engineering

Jiali Meng, Tania Chroumpi, Miia R Mäkelä, Ronald P de Vries

Research output: Contribution to journal/periodicalArticleScientificpeer-review

14 Citations (Scopus)


Xylitol is widely used in the food and pharmaceutical industries as a valuable commodity product. Biotechnological production of xylitol from lignocellulosic biomass by microorganisms is a promising alternative option to chemical synthesis or bioconversion from D-xylose. In this study, four metabolic mutants of Aspergillus niger were constructed and evaluated for xylitol accumulation from D-xylose and lignocellulosic biomass. All mutants had strongly increased xylitol production from pure D-xylose, beechwood xylan, wheat bran and cotton seed hulls compared to the reference strain, but not from several other feed stocks. The triple mutant ΔladAΔxdhAΔsdhA showed the best performance in xylitol production from wheat bran and cotton seed hulls. This study demonstrated the large potential of A. niger for xylitol production directly from lignocellulosic biomass by metabolic engineering.

Original languageEnglish
Pages (from-to)126199
JournalBioresource Technology
Issue numberPt A
Publication statusPublished - Jan 2022


  • Aspergillus niger/genetics
  • Biomass
  • Fermentation
  • Metabolic Engineering
  • Xylitol
  • Xylose


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