Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential

Marizeth Groenewald; Teun Boekhout; Cecile Neuveglise; Claude Gaillardin; Piet W. M. van Dijck; Markus Wyss

doi:10.3109/1040841X.2013.770386

Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential

Marizeth Groenewald, Teun Boekhout, Cecile Neuveglise, Claude Gaillardin, Piet W. M. van Dijck, Markus Wyss

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

Abstract Yarrowia lipolytica has been developed as a production host for a large variety of biotechnological applications. Efficacy and safety studies have demonstrated the safe use of Yarrowia-derived products containing significant proportions of Yarrowia biomass (as for DuPont's eicosapentaenoic acid-rich oil) or with the yeast itself as the final product (as for British Petroleum's single-cell protein product). The natural occurrence of the species in food, particularly cheese, other dairy products and meat, is a further argument supporting its safety. The species causes rare opportunistic infections in severely immunocompromised or otherwise seriously ill people with other underlying diseases or conditions. The infections can be treated effectively by the use of regular antifungal drugs, and in some cases even disappeared spontaneously. Based on our assessment, we conclude that Y. lipolytica is a "safe-to-use" organism.

Original language	English
Pages (from-to)	187-206
Journal	Critical Reviews in Microbiology
Volume	40
Issue number	3
DOIs	https://doi.org/10.3109/1040841X.2013.770386
Publication status	Published - Aug 2014

Keywords

Genomics
industrial application
natural occurrence
opportunistic infection
taxonomy

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10.3109/1040841X.2013.770386

Cite this

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title = "Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential",

abstract = "Abstract Yarrowia lipolytica has been developed as a production host for a large variety of biotechnological applications. Efficacy and safety studies have demonstrated the safe use of Yarrowia-derived products containing significant proportions of Yarrowia biomass (as for DuPont's eicosapentaenoic acid-rich oil) or with the yeast itself as the final product (as for British Petroleum's single-cell protein product). The natural occurrence of the species in food, particularly cheese, other dairy products and meat, is a further argument supporting its safety. The species causes rare opportunistic infections in severely immunocompromised or otherwise seriously ill people with other underlying diseases or conditions. The infections can be treated effectively by the use of regular antifungal drugs, and in some cases even disappeared spontaneously. Based on our assessment, we conclude that Y. lipolytica is a {"}safe-to-use{"} organism.",

keywords = "Genomics, industrial application, natural occurrence, opportunistic infection, taxonomy",

author = "Marizeth Groenewald and Teun Boekhout and Cecile Neuveglise and Claude Gaillardin and {van Dijck}, {Piet W. M.} and Markus Wyss",

note = "Reporting year: 2013",

year = "2014",

month = aug,

doi = "10.3109/1040841X.2013.770386",

language = "English",

volume = "40",

pages = "187--206",

journal = "Critical Reviews in Microbiology",

issn = "1040-841X",

publisher = "Informa Healthcare",

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Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential. / Groenewald, Marizeth ; Boekhout, Teun; Neuveglise, Cecile; Gaillardin, Claude; van Dijck, Piet W. M.; Wyss, Markus.

In: Critical Reviews in Microbiology, Vol. 40, No. 3, 08.2014, p. 187-206.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

TY - JOUR

T1 - Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential

AU - Groenewald, Marizeth

AU - Boekhout, Teun

AU - Neuveglise, Cecile

AU - Gaillardin, Claude

AU - van Dijck, Piet W. M.

AU - Wyss, Markus

N1 - Reporting year: 2013

PY - 2014/8

Y1 - 2014/8

N2 - Abstract Yarrowia lipolytica has been developed as a production host for a large variety of biotechnological applications. Efficacy and safety studies have demonstrated the safe use of Yarrowia-derived products containing significant proportions of Yarrowia biomass (as for DuPont's eicosapentaenoic acid-rich oil) or with the yeast itself as the final product (as for British Petroleum's single-cell protein product). The natural occurrence of the species in food, particularly cheese, other dairy products and meat, is a further argument supporting its safety. The species causes rare opportunistic infections in severely immunocompromised or otherwise seriously ill people with other underlying diseases or conditions. The infections can be treated effectively by the use of regular antifungal drugs, and in some cases even disappeared spontaneously. Based on our assessment, we conclude that Y. lipolytica is a "safe-to-use" organism.

AB - Abstract Yarrowia lipolytica has been developed as a production host for a large variety of biotechnological applications. Efficacy and safety studies have demonstrated the safe use of Yarrowia-derived products containing significant proportions of Yarrowia biomass (as for DuPont's eicosapentaenoic acid-rich oil) or with the yeast itself as the final product (as for British Petroleum's single-cell protein product). The natural occurrence of the species in food, particularly cheese, other dairy products and meat, is a further argument supporting its safety. The species causes rare opportunistic infections in severely immunocompromised or otherwise seriously ill people with other underlying diseases or conditions. The infections can be treated effectively by the use of regular antifungal drugs, and in some cases even disappeared spontaneously. Based on our assessment, we conclude that Y. lipolytica is a "safe-to-use" organism.

KW - Genomics

KW - industrial application

KW - natural occurrence

KW - opportunistic infection

KW - taxonomy

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DO - 10.3109/1040841X.2013.770386

M3 - Article

VL - 40

SP - 187

EP - 206

JO - Critical Reviews in Microbiology

JF - Critical Reviews in Microbiology

SN - 1040-841X

IS - 3

ER -

Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential

Abstract

Keywords

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