Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

Keyphrases

• Zebrafish mutant 100%
• Von Hippel-Lindau 100%
• Von Hippel-Lindau Tumor Suppressor 100%
• Hypoxic Response 100%
• Chuvash Polycythemia 100%
• Zebrafish 60%
• Hematopoiesis 40%
• Polycythemia 40%
• Fertilization 20%
• Human Disease 20%
• Hematopoietic Stem Cells 20%
• Microarray Gene Expression Analysis 20%
• Chemical Activation 20%
• Tumor Suppressor Gene 20%
• Amino Acid Content 20%
• In Situ Hybridization 20%
• Hypoxia 20%
• Associated Diseases 20%
• Hypoxia-inducible Factor 20%
• Genotype-phenotype Correlation 20%
• Erythropoietin 20%
• Accurate Model 20%
• Vertebrate Animals 20%
• Disease Progression 20%
• Germline mutation 20%
• Functional Conservation 20%
• C-Myb 20%
• Hyperventilation 20%
• Gene Orthology 20%
• Hypoxic Signaling 20%
• Erythroid Precursors 20%
• Erythroid Differentiation 20%
• Hematopoietic Tissue 20%
• Hematopoietic Lineage 20%
• EpoR 20%
• Mutant Embryo 20%

Medicine and Dentistry

• Von Hippel-Lindau Tumor Suppressor 100%
• Polycythemia vera 100%
• Hypoxic Response 100%
• Messenger RNA 66%
• Upregulation 66%
• Hematopoiesis 66%
• Diseases 33%
• Amino Acid 33%
• Tumor Suppressor Gene 33%
• Genotype Phenotype Correlation 33%
• Hypoxia Inducible Factor 33%
• Orthology 33%
• Expression Analysis 33%
• Hematopoietic Cell 33%
• Disease Exacerbation 33%
• Precursor 33%
• Hypoxia 33%
• In Situ Hybridization 33%
• Germline Mutation 33%
• Injection 33%
• Fertilization 33%

Biochemistry, Genetics and Molecular Biology

• Zebra fish 100%
• Von Hippel-Lindau Tumor Suppressor 100%
• Messenger RNA 50%
• Upregulation 50%
• Hematopoiesis 50%
• Expression Analysis 25%
• Tumor Suppressor Gene 25%
• In Situ Hybridization 25%
• Amino Acid 25%
• Precursor 25%
• Orthology 25%
• Hypoxia-Inducible Factors 25%
• Hematopoietic Cell 25%
• Germline Mutation 25%
• Erythropoietin 25%
• Vertebrates Animal Model 25%
• N-Myc 25%
• Genotype-Phenotype Correlation 25%
• Fertilization 25%