Zebrafish provides a novel model for lymphatic vascular research

T. Karpanen; S. Schulte-Merker

doi:10.1016/B978-0-12-381320-6.00009-6

Zebrafish provides a novel model for lymphatic vascular research

T. Karpanen, S. Schulte-Merker

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

16 Citations (Scopus)

Abstract

The mammalian lymphatic vasculature has an important function in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, and immune surveillance. The lymphatic vessels are also recruited by many tumors as primary routes for metastasis and mediate immune responses in inflammatory diseases, whereas dysfunction of the lymphatic drainage leads to lymphedema. The characterization of a lymphatic vasculature in zebrafish has made the advantages of this small model organism, the suitability for intravital time-lapse imaging of developmental processes and the amenability for chemical and forward genetic screens, available to lymphatic vascular research. Here we review our current understanding of embryonic lymphangiogenesis in zebrafish, its molecular and anatomical similarities to mammalian lymphatic vascular development, and the possibilities zebrafish offers to complement mouse models and cell culture assays in the lymphangiogenesis field.

Original language	English
Pages (from-to)	223-238
Journal	Methods in Cell Biology
Volume	105
DOIs	https://doi.org/10.1016/B978-0-12-381320-6.00009-6
Publication status	Published - 2011

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title = "Zebrafish provides a novel model for lymphatic vascular research",

abstract = "The mammalian lymphatic vasculature has an important function in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, and immune surveillance. The lymphatic vessels are also recruited by many tumors as primary routes for metastasis and mediate immune responses in inflammatory diseases, whereas dysfunction of the lymphatic drainage leads to lymphedema. The characterization of a lymphatic vasculature in zebrafish has made the advantages of this small model organism, the suitability for intravital time-lapse imaging of developmental processes and the amenability for chemical and forward genetic screens, available to lymphatic vascular research. Here we review our current understanding of embryonic lymphangiogenesis in zebrafish, its molecular and anatomical similarities to mammalian lymphatic vascular development, and the possibilities zebrafish offers to complement mouse models and cell culture assays in the lymphangiogenesis field.",

author = "T. Karpanen and S. Schulte-Merker",

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AU - Schulte-Merker, S.

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AB - The mammalian lymphatic vasculature has an important function in the maintenance of tissue fluid homeostasis, absorption of dietary lipids, and immune surveillance. The lymphatic vessels are also recruited by many tumors as primary routes for metastasis and mediate immune responses in inflammatory diseases, whereas dysfunction of the lymphatic drainage leads to lymphedema. The characterization of a lymphatic vasculature in zebrafish has made the advantages of this small model organism, the suitability for intravital time-lapse imaging of developmental processes and the amenability for chemical and forward genetic screens, available to lymphatic vascular research. Here we review our current understanding of embryonic lymphangiogenesis in zebrafish, its molecular and anatomical similarities to mammalian lymphatic vascular development, and the possibilities zebrafish offers to complement mouse models and cell culture assays in the lymphangiogenesis field.

U2 - 10.1016/B978-0-12-381320-6.00009-6

DO - 10.1016/B978-0-12-381320-6.00009-6

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SN - 0091-679X

VL - 105

SP - 223

EP - 238

JO - Methods in Cell Biology

JF - Methods in Cell Biology

ER -

Zebrafish provides a novel model for lymphatic vascular research

Abstract

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