β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression

TY - JOUR

T1 - β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression

AU - Mavrommati, Ioanna

AU - Faedda, Roberta

AU - Galasso, Giovanni

AU - Li, Jie

AU - Burdova, Kamila

AU - Fischer, Roman

AU - Kessler, Benedikt M

AU - Carrero, Zunamys I

AU - Guardavaccaro, Daniele

AU - Pagano, Michele

AU - D'Angiolella, Vincenzo

N1 - Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.

PY - 2018/9/25

Y1 - 2018/9/25

N2 - Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell-cycle phase. The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. Cyclin F has important functions in regulating the cell cycle during the G2 checkpoint; however, the mechanisms underlying the regulation of cyclin F are poorly understood. Here, we observe that cyclin F is regulated by proteolysis through β-TrCP. β-TrCP recognizes cyclin F through a non-canonical degron site (TSGXXS) after its phosphorylation by casein kinase II. The degradation of cyclin F mediated by β-TrCP occurs at the G2/M transition. This event is required to promote mitotic progression and favors the activation of a transcriptional program required for mitosis.

AB - Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell-cycle phase. The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. Cyclin F has important functions in regulating the cell cycle during the G2 checkpoint; however, the mechanisms underlying the regulation of cyclin F are poorly understood. Here, we observe that cyclin F is regulated by proteolysis through β-TrCP. β-TrCP recognizes cyclin F through a non-canonical degron site (TSGXXS) after its phosphorylation by casein kinase II. The degradation of cyclin F mediated by β-TrCP occurs at the G2/M transition. This event is required to promote mitotic progression and favors the activation of a transcriptional program required for mitosis.

U2 - 10.1016/j.celrep.2018.08.076

DO - 10.1016/j.celrep.2018.08.076

M3 - Article

C2 - 30257202

SN - 2211-1247

VL - 24

SP - 3404

EP - 3412

JO - Cell Reports

JF - Cell Reports

IS - 13

ER -