A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior.

M Ahmadlou; J.H.W. Houba; J.F.M. Van Vierbergen; M. Giannouli; G.A. Gimenez; C. Van Weeghel; M. Darbanfouladi; M.Y. Shirazi; J. Dziubek; M. Kacem; Fred De Winter; J.A. Heimel

A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior.

M Ahmadlou, J.H.W. Houba, J.F.M. Van Vierbergen, M. Giannouli, G.A. Gimenez, C. Van Weeghel, M. Darbanfouladi, M.Y. Shirazi, J. Dziubek, M. Kacem, Fred De Winter, J.A. Heimel

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Exploring the physical and social environment is essential for understanding the surrounding world. We do not know how novelty-seeking motivation initiates the complex sequence of actions that make up investigatory behavior. We found in mice that inhibitory neurons in the medial zona incerta (ZIm), a subthalamic brain region, are essential for the decision to investigate an object or a conspecific. These neurons receive excitatory input from the prelimbic cortex to signal the initiation of exploration. This signal is modulated in the ZIm by the level of investigatory motivation. Increased activity in the ZIm instigates deep investigative action by inhibiting the periaqueductal gray region. A subpopulation of inhibitory ZIm neurons expressing tachykinin 1 (TAC1) modulates the investigatory behavior.

Originele taal-2	Engels
Artikelnummer	eabe9681
Tijdschrift	Science
Volume	372
Status	Gepubliceerd - 14 mei 2021

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title = "A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior.",

abstract = "Exploring the physical and social environment is essential for understanding the surrounding world. We do not know how novelty-seeking motivation initiates the complex sequence of actions that make up investigatory behavior. We found in mice that inhibitory neurons in the medial zona incerta (ZIm), a subthalamic brain region, are essential for the decision to investigate an object or a conspecific. These neurons receive excitatory input from the prelimbic cortex to signal the initiation of exploration. This signal is modulated in the ZIm by the level of investigatory motivation. Increased activity in the ZIm instigates deep investigative action by inhibiting the periaqueductal gray region. A subpopulation of inhibitory ZIm neurons expressing tachykinin 1 (TAC1) modulates the investigatory behavior.",

author = "M Ahmadlou and J.H.W. Houba and {Van Vierbergen}, J.F.M. and M. Giannouli and G.A. Gimenez and {Van Weeghel}, C. and M. Darbanfouladi and M.Y. Shirazi and J. Dziubek and M. Kacem and {De Winter}, Fred and J.A. Heimel",

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AU - Ahmadlou, M

AU - Houba, J.H.W.

AU - Van Vierbergen, J.F.M.

AU - Giannouli, M.

AU - Gimenez, G.A.

AU - Van Weeghel, C.

AU - Darbanfouladi, M.

AU - Shirazi, M.Y.

AU - Dziubek, J.

AU - Kacem, M.

AU - De Winter, Fred

AU - Heimel, J.A.

PY - 2021/5/14

Y1 - 2021/5/14

N2 - Exploring the physical and social environment is essential for understanding the surrounding world. We do not know how novelty-seeking motivation initiates the complex sequence of actions that make up investigatory behavior. We found in mice that inhibitory neurons in the medial zona incerta (ZIm), a subthalamic brain region, are essential for the decision to investigate an object or a conspecific. These neurons receive excitatory input from the prelimbic cortex to signal the initiation of exploration. This signal is modulated in the ZIm by the level of investigatory motivation. Increased activity in the ZIm instigates deep investigative action by inhibiting the periaqueductal gray region. A subpopulation of inhibitory ZIm neurons expressing tachykinin 1 (TAC1) modulates the investigatory behavior.

AB - Exploring the physical and social environment is essential for understanding the surrounding world. We do not know how novelty-seeking motivation initiates the complex sequence of actions that make up investigatory behavior. We found in mice that inhibitory neurons in the medial zona incerta (ZIm), a subthalamic brain region, are essential for the decision to investigate an object or a conspecific. These neurons receive excitatory input from the prelimbic cortex to signal the initiation of exploration. This signal is modulated in the ZIm by the level of investigatory motivation. Increased activity in the ZIm instigates deep investigative action by inhibiting the periaqueductal gray region. A subpopulation of inhibitory ZIm neurons expressing tachykinin 1 (TAC1) modulates the investigatory behavior.

M3 - Article

SN - 0036-8075

VL - 372

JO - Science

JF - Science

M1 - eabe9681

ER -

A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior.

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