A 7T fMRI investigation of hand and tool areas in the lateral and ventral occipitotemporal cortex

Ineke Pillet; Begüm Cerrahoğlu; Roxane Victoria Philips; Serge Dumoulin; Hans Op de Beeck

doi:10.1371/journal.pone.0308565

A 7T fMRI investigation of hand and tool areas in the lateral and ventral occipitotemporal cortex

Ineke Pillet, Begüm Cerrahoğlu, Roxane Victoria Philips, Serge Dumoulin, Hans Op de Beeck

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Previous studies demonstrated the existence of hand and tool areas in lateral and ventral occipitotemporal cortex (OTC), as well as an overlap between them. We reinvestigated this organization using 7T fMRI, benefiting from a higher signal-to-noise ratio than 3T. This enabled us to include a wider array of categories to achieve a more holistic perspective, and to omit certain spatial preprocessing steps. Despite these improvements, univariate analysis confirmed the existence of hand-tool overlap across OTC, which is striking given the omission of the spatial preprocessing steps that can influence overlap. There was significantly more overlap between hands and tools, compared to other overlap types in the left hemisphere of OTC. The overlap was also larger in the left lateral OTC as compared to the right lateral OTC. We found in all hand areas a differentiation between tools and other types of objects, although they still responded more to bodies than to tools. Regarding the tool areas, we observed a differentiation between hands and other categories such as faces and non-tool objects. Left hemisphere tool areas also differentiated between hands and bodies. When excluding the overlapping voxels from the hand and tool areas, they still showed a significant response to tools or hands (compared to objects or faces) respectively. Multi-voxel pattern analysis indicated that neural representations in the hand areas showed greater similarity between hands and tools than between hands and other objects. In the tool areas, the neural representations between tools and hands and between tools and other type of objects were all equally similar. To summarize, capitalizing on the benefits of 7T fMRI, we further substantiate the evidence in favor of hand-tool overlap in several regions of occipitotemporal cortex.

Originele taal-2	Engels
Pagina's (van-tot)	e0308565
Tijdschrift	PLoS ONE
Volume	19
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.1371/journal.pone.0308565
Status	Gepubliceerd - nov. 2024

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10.1371/journal.pone.0308565

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title = "A 7T fMRI investigation of hand and tool areas in the lateral and ventral occipitotemporal cortex",

abstract = "Previous studies demonstrated the existence of hand and tool areas in lateral and ventral occipitotemporal cortex (OTC), as well as an overlap between them. We reinvestigated this organization using 7T fMRI, benefiting from a higher signal-to-noise ratio than 3T. This enabled us to include a wider array of categories to achieve a more holistic perspective, and to omit certain spatial preprocessing steps. Despite these improvements, univariate analysis confirmed the existence of hand-tool overlap across OTC, which is striking given the omission of the spatial preprocessing steps that can influence overlap. There was significantly more overlap between hands and tools, compared to other overlap types in the left hemisphere of OTC. The overlap was also larger in the left lateral OTC as compared to the right lateral OTC. We found in all hand areas a differentiation between tools and other types of objects, although they still responded more to bodies than to tools. Regarding the tool areas, we observed a differentiation between hands and other categories such as faces and non-tool objects. Left hemisphere tool areas also differentiated between hands and bodies. When excluding the overlapping voxels from the hand and tool areas, they still showed a significant response to tools or hands (compared to objects or faces) respectively. Multi-voxel pattern analysis indicated that neural representations in the hand areas showed greater similarity between hands and tools than between hands and other objects. In the tool areas, the neural representations between tools and hands and between tools and other type of objects were all equally similar. To summarize, capitalizing on the benefits of 7T fMRI, we further substantiate the evidence in favor of hand-tool overlap in several regions of occipitotemporal cortex.",

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author = "Ineke Pillet and Beg{\"u}m Cerrahoğlu and Philips, {Roxane Victoria} and Serge Dumoulin and {Op de Beeck}, Hans",

note = "Copyright: {\textcopyright} 2024 Pillet et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

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month = nov,

doi = "10.1371/journal.pone.0308565",

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T1 - A 7T fMRI investigation of hand and tool areas in the lateral and ventral occipitotemporal cortex

AU - Pillet, Ineke

AU - Cerrahoğlu, Begüm

AU - Philips, Roxane Victoria

AU - Dumoulin, Serge

AU - Op de Beeck, Hans

N1 - Copyright: © 2024 Pillet et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2024/11

Y1 - 2024/11

N2 - Previous studies demonstrated the existence of hand and tool areas in lateral and ventral occipitotemporal cortex (OTC), as well as an overlap between them. We reinvestigated this organization using 7T fMRI, benefiting from a higher signal-to-noise ratio than 3T. This enabled us to include a wider array of categories to achieve a more holistic perspective, and to omit certain spatial preprocessing steps. Despite these improvements, univariate analysis confirmed the existence of hand-tool overlap across OTC, which is striking given the omission of the spatial preprocessing steps that can influence overlap. There was significantly more overlap between hands and tools, compared to other overlap types in the left hemisphere of OTC. The overlap was also larger in the left lateral OTC as compared to the right lateral OTC. We found in all hand areas a differentiation between tools and other types of objects, although they still responded more to bodies than to tools. Regarding the tool areas, we observed a differentiation between hands and other categories such as faces and non-tool objects. Left hemisphere tool areas also differentiated between hands and bodies. When excluding the overlapping voxels from the hand and tool areas, they still showed a significant response to tools or hands (compared to objects or faces) respectively. Multi-voxel pattern analysis indicated that neural representations in the hand areas showed greater similarity between hands and tools than between hands and other objects. In the tool areas, the neural representations between tools and hands and between tools and other type of objects were all equally similar. To summarize, capitalizing on the benefits of 7T fMRI, we further substantiate the evidence in favor of hand-tool overlap in several regions of occipitotemporal cortex.

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KW - Magnetic Resonance Imaging/methods

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KW - Male

KW - Female

KW - Temporal Lobe/physiology

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KW - Brain Mapping/methods

KW - Occipital Lobe/physiology

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