A Comparison of the Biotechnological Potential of Marine and Terrestrial Species of Two Orders of Sordariomycete Fungi

Raquel Ledo Doval; Astrid Müller; Daren W Brown; Derek Johnson; C Alisha Quandt; Kerrie Barry; Alicia Clum; Hope Hundley; Kurt LaButti; Anna Lipzen; Stephen J Mondo; Robin A Ohm; Jasmyn L Pangilinan; Robert W Riley; Andrei S Steindorff; Mei Wang; Elodie Drula; Bernard Henrissat; Kathryn Bushley; Joseph W Spatafora; Mao Peng; Igor V Grigoriev; Ronald P de Vries

doi:10.1007/s10126-025-10484-3

A Comparison of the Biotechnological Potential of Marine and Terrestrial Species of Two Orders of Sordariomycete Fungi

Raquel Ledo Doval, Astrid Müller, Daren W Brown, Derek Johnson, C Alisha Quandt, Kerrie Barry, Alicia Clum, Hope Hundley, Kurt LaButti, Anna Lipzen, Stephen J Mondo, Robin A Ohm, Jasmyn L Pangilinan, Robert W Riley, Andrei S Steindorff, Mei Wang, Elodie Drula, Bernard Henrissat, Kathryn Bushley, Joseph W SpataforaMao Peng, Igor V Grigoriev, Ronald P de Vries

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Marine fungi have been receiving increasing interest, especially with respect to their potential for biotechnological applications. Carbon sources in marine environments, such as seaweeds, have cell walls that are structurally different from the cell walls of terrestrial plants, which implies that marine fungi likely possess a specific set of extracellular enzymes to enable them to use these marine substrates as carbon and energy source. In addition, marine fungi have been implicated as good sources of secondary metabolites with bioactive functions, as e.g., drugs and antibiotics. To evaluate if marine fungi have genomic signatures that distinguish them from terrestrial fungi with respect to biotechnological potential, we genome-sequenced three marine fungal species (Varicosporina prolifera, Corollospora maritima, Emericellopsis maritima), two terrestrial species (Clonostachys rosea, Stanjemonium grisellum), and one that is found in both terrestrial and marine environments (Microascus triganosporus) and compared them to taxonomically-related terrestrial (Microascus stellatus, Valetoniellopsis laxa) and marine species (Emericellopsis atlantica) for which genomes were already available. These fungi originate from two orders (Microascales, Hypocreales) of the Sordariomycetes. We then compared their carbohydrate-active enzymes and secondary metabolism content and their ability to use terrestrial and marine biomass as carbon sources. The analysis revealed that despite the presence of some genes specific to marine fungi, no general genomic or growth phenotypes can be identified to distinguish marine fungi from terrestrial fungi, suggesting that all have maintained the ability to use both marine and terrestrial carbon sources.

Originele taal-2	Engels
Pagina's (van-tot)	103
Tijdschrift	Marine biotechnology (New York, N.Y.)
Volume	27
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1007/s10126-025-10484-3
Status	Gepubliceerd - 25 jun. 2025

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10.1007/s10126-025-10484-3

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Doval, R. L., Müller, A., Brown, D. W., Johnson, D., Quandt, C. A., Barry, K., Clum, A., Hundley, H., LaButti, K., Lipzen, A., Mondo, S. J., Ohm, R. A., Pangilinan, J. L., Riley, R. W., Steindorff, A. S., Wang, M., Drula, E., Henrissat, B., Bushley, K., ... de Vries, R. P. (2025). A Comparison of the Biotechnological Potential of Marine and Terrestrial Species of Two Orders of Sordariomycete Fungi. Marine biotechnology (New York, N.Y.), 27(4), 103. https://doi.org/10.1007/s10126-025-10484-3

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title = "A Comparison of the Biotechnological Potential of Marine and Terrestrial Species of Two Orders of Sordariomycete Fungi",

abstract = "Marine fungi have been receiving increasing interest, especially with respect to their potential for biotechnological applications. Carbon sources in marine environments, such as seaweeds, have cell walls that are structurally different from the cell walls of terrestrial plants, which implies that marine fungi likely possess a specific set of extracellular enzymes to enable them to use these marine substrates as carbon and energy source. In addition, marine fungi have been implicated as good sources of secondary metabolites with bioactive functions, as e.g., drugs and antibiotics. To evaluate if marine fungi have genomic signatures that distinguish them from terrestrial fungi with respect to biotechnological potential, we genome-sequenced three marine fungal species (Varicosporina prolifera, Corollospora maritima, Emericellopsis maritima), two terrestrial species (Clonostachys rosea, Stanjemonium grisellum), and one that is found in both terrestrial and marine environments (Microascus triganosporus) and compared them to taxonomically-related terrestrial (Microascus stellatus, Valetoniellopsis laxa) and marine species (Emericellopsis atlantica) for which genomes were already available. These fungi originate from two orders (Microascales, Hypocreales) of the Sordariomycetes. We then compared their carbohydrate-active enzymes and secondary metabolism content and their ability to use terrestrial and marine biomass as carbon sources. The analysis revealed that despite the presence of some genes specific to marine fungi, no general genomic or growth phenotypes can be identified to distinguish marine fungi from terrestrial fungi, suggesting that all have maintained the ability to use both marine and terrestrial carbon sources.",

keywords = "Genome, Fungal, Biotechnology, Phylogeny, Hypocreales/genetics, Aquatic Organisms",

author = "Doval, {Raquel Ledo} and Astrid M{\"u}ller and Brown, {Daren W} and Derek Johnson and Quandt, {C Alisha} and Kerrie Barry and Alicia Clum and Hope Hundley and Kurt LaButti and Anna Lipzen and Mondo, {Stephen J} and Ohm, {Robin A} and Pangilinan, {Jasmyn L} and Riley, {Robert W} and Steindorff, {Andrei S} and Mei Wang and Elodie Drula and Bernard Henrissat and Kathryn Bushley and Spatafora, {Joseph W} and Mao Peng and Grigoriev, {Igor V} and {de Vries}, {Ronald P}",

note = "{\textcopyright} 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

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Doval, RL, Müller, A, Brown, DW, Johnson, D, Quandt, CA, Barry, K, Clum, A, Hundley, H, LaButti, K, Lipzen, A, Mondo, SJ, Ohm, RA, Pangilinan, JL, Riley, RW, Steindorff, AS, Wang, M, Drula, E, Henrissat, B, Bushley, K, Spatafora, JW, Peng, M, Grigoriev, IV & de Vries, RP 2025, 'A Comparison of the Biotechnological Potential of Marine and Terrestrial Species of Two Orders of Sordariomycete Fungi', Marine biotechnology (New York, N.Y.), vol. 27, nr. 4, blz. 103. https://doi.org/10.1007/s10126-025-10484-3

A Comparison of the Biotechnological Potential of Marine and Terrestrial Species of Two Orders of Sordariomycete Fungi. / Doval, Raquel Ledo; Müller, Astrid; Brown, Daren W et al.
In: Marine biotechnology (New York, N.Y.), Vol. 27, Nr. 4, 25.06.2025, blz. 103.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

TY - JOUR

T1 - A Comparison of the Biotechnological Potential of Marine and Terrestrial Species of Two Orders of Sordariomycete Fungi

AU - Doval, Raquel Ledo

AU - Müller, Astrid

AU - Brown, Daren W

AU - Johnson, Derek

AU - Quandt, C Alisha

AU - Barry, Kerrie

AU - Clum, Alicia

AU - Hundley, Hope

AU - LaButti, Kurt

AU - Lipzen, Anna

AU - Mondo, Stephen J

AU - Ohm, Robin A

AU - Pangilinan, Jasmyn L

AU - Riley, Robert W

AU - Steindorff, Andrei S

AU - Wang, Mei

AU - Drula, Elodie

AU - Henrissat, Bernard

AU - Bushley, Kathryn

AU - Spatafora, Joseph W

AU - Peng, Mao

AU - Grigoriev, Igor V

AU - de Vries, Ronald P

PY - 2025/6/25

Y1 - 2025/6/25

N2 - Marine fungi have been receiving increasing interest, especially with respect to their potential for biotechnological applications. Carbon sources in marine environments, such as seaweeds, have cell walls that are structurally different from the cell walls of terrestrial plants, which implies that marine fungi likely possess a specific set of extracellular enzymes to enable them to use these marine substrates as carbon and energy source. In addition, marine fungi have been implicated as good sources of secondary metabolites with bioactive functions, as e.g., drugs and antibiotics. To evaluate if marine fungi have genomic signatures that distinguish them from terrestrial fungi with respect to biotechnological potential, we genome-sequenced three marine fungal species (Varicosporina prolifera, Corollospora maritima, Emericellopsis maritima), two terrestrial species (Clonostachys rosea, Stanjemonium grisellum), and one that is found in both terrestrial and marine environments (Microascus triganosporus) and compared them to taxonomically-related terrestrial (Microascus stellatus, Valetoniellopsis laxa) and marine species (Emericellopsis atlantica) for which genomes were already available. These fungi originate from two orders (Microascales, Hypocreales) of the Sordariomycetes. We then compared their carbohydrate-active enzymes and secondary metabolism content and their ability to use terrestrial and marine biomass as carbon sources. The analysis revealed that despite the presence of some genes specific to marine fungi, no general genomic or growth phenotypes can be identified to distinguish marine fungi from terrestrial fungi, suggesting that all have maintained the ability to use both marine and terrestrial carbon sources.

AB - Marine fungi have been receiving increasing interest, especially with respect to their potential for biotechnological applications. Carbon sources in marine environments, such as seaweeds, have cell walls that are structurally different from the cell walls of terrestrial plants, which implies that marine fungi likely possess a specific set of extracellular enzymes to enable them to use these marine substrates as carbon and energy source. In addition, marine fungi have been implicated as good sources of secondary metabolites with bioactive functions, as e.g., drugs and antibiotics. To evaluate if marine fungi have genomic signatures that distinguish them from terrestrial fungi with respect to biotechnological potential, we genome-sequenced three marine fungal species (Varicosporina prolifera, Corollospora maritima, Emericellopsis maritima), two terrestrial species (Clonostachys rosea, Stanjemonium grisellum), and one that is found in both terrestrial and marine environments (Microascus triganosporus) and compared them to taxonomically-related terrestrial (Microascus stellatus, Valetoniellopsis laxa) and marine species (Emericellopsis atlantica) for which genomes were already available. These fungi originate from two orders (Microascales, Hypocreales) of the Sordariomycetes. We then compared their carbohydrate-active enzymes and secondary metabolism content and their ability to use terrestrial and marine biomass as carbon sources. The analysis revealed that despite the presence of some genes specific to marine fungi, no general genomic or growth phenotypes can be identified to distinguish marine fungi from terrestrial fungi, suggesting that all have maintained the ability to use both marine and terrestrial carbon sources.

KW - Genome, Fungal

KW - Biotechnology

KW - Phylogeny

KW - Hypocreales/genetics

KW - Aquatic Organisms

U2 - 10.1007/s10126-025-10484-3

DO - 10.1007/s10126-025-10484-3

M3 - Article

C2 - 40560406

SN - 1436-2228

VL - 27

SP - 103

JO - Marine biotechnology (New York, N.Y.)

JF - Marine biotechnology (New York, N.Y.)

IS - 4

ER -

A Comparison of the Biotechnological Potential of Marine and Terrestrial Species of Two Orders of Sordariomycete Fungi

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