@article{0ddd48f1e2474d7f8fc39ff1c665548f,
title = "A path to translation: How 3D patient tumor avatars enable next generation precision oncology",
abstract = "3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine. Here, we describe the benefits and challenges of 3D-PTA technologies and necessary future steps to realize their potential for clinical decision making. 3D-PTAs require standardization criteria and prospective trials to establish clinical benefits. Innovative trial designs that combine omics and 3D-PTA readouts may lead to more accurate clinical predictors, and an integrated platform that combines diagnostic and therapeutic development will accelerate new treatments for patients with refractory disease.",
author = "Margarida Barroso and Chheda, {Milan G} and Hans Clevers and Elena Elez and Salma Kaochar and Kopetz, {Scott E} and Xiao-Nan Li and Funda Meric-Bernstam and Meyer, {Clifford A} and Haiwei Mou and Naegle, {Kristen M} and Pera, {Martin F} and Zinaida Perova and Politi, {Katerina A} and Raphael, {Benjamin J} and Paul Robson and Sears, {Rosalie C} and Josep Tabernero and Tuveson, {David A} and Welm, {Alana L} and Welm, {Bryan E} and Willey, {Christopher D} and Konstantin Salnikow and Chuang, {Jeffrey H} and Xiling Shen",
note = "Copyright {\textcopyright} 2022 Elsevier Inc. All rights reserved.",
year = "2022",
month = oct,
day = "18",
doi = "10.1016/j.ccell.2022.09.017",
language = "English",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
}