Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance

TY - JOUR

T1 - Adult hippocampal neurogenesis in Alzheimer's disease

T2 - A roadmap to clinical relevance

AU - Salta, Evgenia

AU - Lazarov, Orly

AU - Fitzsimons, Carlos P

AU - Tanzi, Rudolph

AU - Lucassen, Paul J

AU - Choi, Se Hoon

N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2023/2/2

Y1 - 2023/2/2

N2 - Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients. Understanding AHN regulation in AD could provide a framework for innovative pharmacological interventions. We here combine molecular, behavioral, and clinical data and critically discuss the multicellular complexity of the AHN niche in relation to AD pathophysiology. We further present a roadmap toward a better understanding of the role of AHN in AD by probing the promises and caveats of the latest technological advancements in the field and addressing the conceptual and methodological challenges ahead.

AB - Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients. Understanding AHN regulation in AD could provide a framework for innovative pharmacological interventions. We here combine molecular, behavioral, and clinical data and critically discuss the multicellular complexity of the AHN niche in relation to AD pathophysiology. We further present a roadmap toward a better understanding of the role of AHN in AD by probing the promises and caveats of the latest technological advancements in the field and addressing the conceptual and methodological challenges ahead.

U2 - 10.1016/j.stem.2023.01.002

DO - 10.1016/j.stem.2023.01.002

M3 - Article

C2 - 36736288

SN - 1934-5909

VL - 30

SP - 120

EP - 136

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 2

ER -