Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

Paul J Lucassen; Carlos P Fitzsimons; Evgenia Salta; Mirjana Maletic-Savatic

doi:10.1016/j.bbr.2019.112458

Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

Paul J Lucassen, Carlos P Fitzsimons, Evgenia Salta, Mirjana Maletic-Savatic

NIN

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

68 Citaten (Scopus)

395 Downloads (Pure)

Samenvatting

In this perspective article, we reflect on the recent debate about the existence of human neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and functional relevance, of new neurons in the adult and aged human hippocampus. To explain the discrepancies between several prominently published human studies, we discuss critical methodological aspects and highlight the importance of optimal tissue preservation and processing for histological examination. We further discuss novel approaches, like single-cell/nucleus sequencing and magnetic resonance spectroscopy, that will help advance the study of human neurogenesis to its fullest potential - understanding its contribution to human hippocampal functions and related disorders like depression and dementia.

Originele taal-2	Engels
Pagina's (van-tot)	112458
Tijdschrift	Behavioural Brain Research
Volume	381
DOI's	https://doi.org/10.1016/j.bbr.2019.112458
Status	Gepubliceerd - 2020

Toegang tot document

10.1016/j.bbr.2019.112458

LucassenFinal published version, 749 KBLicentie: CC BY-NC-ND

Citeer dit

@article{4170f36759034cf097234e748bdfd57e,

title = "Adult neurogenesis, human after all (again): Classic, optimized, and future approaches",

abstract = "In this perspective article, we reflect on the recent debate about the existence of human neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and functional relevance, of new neurons in the adult and aged human hippocampus. To explain the discrepancies between several prominently published human studies, we discuss critical methodological aspects and highlight the importance of optimal tissue preservation and processing for histological examination. We further discuss novel approaches, like single-cell/nucleus sequencing and magnetic resonance spectroscopy, that will help advance the study of human neurogenesis to its fullest potential - understanding its contribution to human hippocampal functions and related disorders like depression and dementia.",

author = "Lucassen, {Paul J} and Fitzsimons, {Carlos P} and Evgenia Salta and Mirjana Maletic-Savatic",

year = "2020",

doi = "10.1016/j.bbr.2019.112458",

language = "English",

volume = "381",

pages = "112458",

journal = "Behavioural Brain Research",

issn = "0166-4328",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Adult neurogenesis, human after all (again)

T2 - Classic, optimized, and future approaches

AU - Lucassen, Paul J

AU - Fitzsimons, Carlos P

AU - Salta, Evgenia

AU - Maletic-Savatic, Mirjana

PY - 2020

Y1 - 2020

N2 - In this perspective article, we reflect on the recent debate about the existence of human neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and functional relevance, of new neurons in the adult and aged human hippocampus. To explain the discrepancies between several prominently published human studies, we discuss critical methodological aspects and highlight the importance of optimal tissue preservation and processing for histological examination. We further discuss novel approaches, like single-cell/nucleus sequencing and magnetic resonance spectroscopy, that will help advance the study of human neurogenesis to its fullest potential - understanding its contribution to human hippocampal functions and related disorders like depression and dementia.

AB - In this perspective article, we reflect on the recent debate about the existence of human neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and functional relevance, of new neurons in the adult and aged human hippocampus. To explain the discrepancies between several prominently published human studies, we discuss critical methodological aspects and highlight the importance of optimal tissue preservation and processing for histological examination. We further discuss novel approaches, like single-cell/nucleus sequencing and magnetic resonance spectroscopy, that will help advance the study of human neurogenesis to its fullest potential - understanding its contribution to human hippocampal functions and related disorders like depression and dementia.

U2 - 10.1016/j.bbr.2019.112458

DO - 10.1016/j.bbr.2019.112458

M3 - Article

C2 - 31899214

SN - 0166-4328

VL - 381

SP - 112458

JO - Behavioural Brain Research

JF - Behavioural Brain Research

ER -

Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit