Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization

Jessica P Y Hua; Siemon C de Lange; Martijn P van den Heuvel; Cassandra L Boness; Constantine J Trela; Yoanna E McDowell; Anne M Merrill; Thomas M Piasecki; Kenneth J Sher; John G Kerns

doi:10.1016/j.drugalcdep.2021.109198

Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization

Jessica P Y Hua, Siemon C de Lange, Martijn P van den Heuvel, Cassandra L Boness, Constantine J Trela, Yoanna E McDowell, Anne M Merrill, Thomas M Piasecki, Kenneth J Sher, John G Kerns

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Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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BACKGROUND: Emerging adulthood is a critical neurodevelopmental stage, with alcohol use during this period consistently associated with brain abnormalities and damage in anatomical structure and white matter integrity. However, it is less clear how alcohol use is associated with the brain's structural organization (i.e., white matter connections between anatomical regions). Recent connectome research has focused on rich-club regions, a collection of highly-interconnected hubs that are critical in brain communication and global network organization and disproportionately vulnerable to insults.

METHODS: For the first time, we examined alcohol use associations with structural rich-club and connectome organization in emerging adults (N = 66).

RESULTS: Greater lifetime drinks and current monthly drinks were significantly associated with lower rich-club organization (rs =-0.38, ps < 0.003) and lower rich-club connectivity (rs <-0.34, ps < 0.007). Additionally, rich-club connectivity was significantly more negatively correlated with alcohol use than connectivity among non-rich-club regions (ps < 0.035). Examining overall structural organization, greater lifetime drinks and current monthly drinks were significantly associated with lower network density (i.e., lower network resilience; rs <-0.36, ps = 0.004). Additionally, greater lifetime drinks and current monthly drinks were significantly associated with higher network segregation (i.e., network's tendency to divide into subnetworks; rs >0.33, ps<0.008). Alcohol use was not significantly associated with network integration (i.e., network's efficiency in combining information across the brain; ps > 0.064).

CONCLUSIONS: Results provide novel evidence that alcohol use is associated with decreased rich-club connectivity and structural network disorganization. Given that both are critical in global brain communication, these results highlight the importance of examining alcohol use and brain relationships in emerging adulthood.

Originele taal-2	Engels
Pagina's (van-tot)	109198
Tijdschrift	Drug and Alcohol Dependence
Volume	230
DOI's	https://doi.org/10.1016/j.drugalcdep.2021.109198
Status	Gepubliceerd - 2022

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10.1016/j.drugalcdep.2021.109198

hua2022Accepted author manuscript, 935 KBLicentie: CC BY-NC-ND

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Hua, J. P. Y., de Lange, S. C., van den Heuvel, M. P., Boness, C. L., Trela, C. J., McDowell, Y. E., Merrill, A. M., Piasecki, T. M., Sher, K. J., & Kerns, J. G. (2022). Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization. Drug and Alcohol Dependence, 230, 109198. https://doi.org/10.1016/j.drugalcdep.2021.109198

@article{e74c3bbe039c413292304ceadf5b1238,

title = "Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization",

abstract = "BACKGROUND: Emerging adulthood is a critical neurodevelopmental stage, with alcohol use during this period consistently associated with brain abnormalities and damage in anatomical structure and white matter integrity. However, it is less clear how alcohol use is associated with the brain's structural organization (i.e., white matter connections between anatomical regions). Recent connectome research has focused on rich-club regions, a collection of highly-interconnected hubs that are critical in brain communication and global network organization and disproportionately vulnerable to insults.METHODS: For the first time, we examined alcohol use associations with structural rich-club and connectome organization in emerging adults (N = 66).RESULTS: Greater lifetime drinks and current monthly drinks were significantly associated with lower rich-club organization (rs =-0.38, ps < 0.003) and lower rich-club connectivity (rs <-0.34, ps < 0.007). Additionally, rich-club connectivity was significantly more negatively correlated with alcohol use than connectivity among non-rich-club regions (ps < 0.035). Examining overall structural organization, greater lifetime drinks and current monthly drinks were significantly associated with lower network density (i.e., lower network resilience; rs <-0.36, ps = 0.004). Additionally, greater lifetime drinks and current monthly drinks were significantly associated with higher network segregation (i.e., network's tendency to divide into subnetworks; rs >0.33, ps<0.008). Alcohol use was not significantly associated with network integration (i.e., network's efficiency in combining information across the brain; ps > 0.064).CONCLUSIONS: Results provide novel evidence that alcohol use is associated with decreased rich-club connectivity and structural network disorganization. Given that both are critical in global brain communication, these results highlight the importance of examining alcohol use and brain relationships in emerging adulthood.",

author = "Hua, {Jessica P Y} and {de Lange}, {Siemon C} and {van den Heuvel}, {Martijn P} and Boness, {Cassandra L} and Trela, {Constantine J} and McDowell, {Yoanna E} and Merrill, {Anne M} and Piasecki, {Thomas M} and Sher, {Kenneth J} and Kerns, {John G}",

note = "Published by Elsevier B.V.",

year = "2022",

doi = "10.1016/j.drugalcdep.2021.109198",

language = "English",

volume = "230",

pages = "109198",

journal = "Drug and Alcohol Dependence",

issn = "0376-8716",

publisher = "Elsevier Ireland Ltd",

}

Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization. / Hua, Jessica P Y; de Lange, Siemon C; van den Heuvel, Martijn P et al.
In: Drug and Alcohol Dependence, Vol. 230, 2022, blz. 109198.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

TY - JOUR

T1 - Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization

AU - Hua, Jessica P Y

AU - de Lange, Siemon C

AU - van den Heuvel, Martijn P

AU - Boness, Cassandra L

AU - Trela, Constantine J

AU - McDowell, Yoanna E

AU - Merrill, Anne M

AU - Piasecki, Thomas M

AU - Sher, Kenneth J

AU - Kerns, John G

N1 - Published by Elsevier B.V.

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Emerging adulthood is a critical neurodevelopmental stage, with alcohol use during this period consistently associated with brain abnormalities and damage in anatomical structure and white matter integrity. However, it is less clear how alcohol use is associated with the brain's structural organization (i.e., white matter connections between anatomical regions). Recent connectome research has focused on rich-club regions, a collection of highly-interconnected hubs that are critical in brain communication and global network organization and disproportionately vulnerable to insults.METHODS: For the first time, we examined alcohol use associations with structural rich-club and connectome organization in emerging adults (N = 66).RESULTS: Greater lifetime drinks and current monthly drinks were significantly associated with lower rich-club organization (rs =-0.38, ps < 0.003) and lower rich-club connectivity (rs <-0.34, ps < 0.007). Additionally, rich-club connectivity was significantly more negatively correlated with alcohol use than connectivity among non-rich-club regions (ps < 0.035). Examining overall structural organization, greater lifetime drinks and current monthly drinks were significantly associated with lower network density (i.e., lower network resilience; rs <-0.36, ps = 0.004). Additionally, greater lifetime drinks and current monthly drinks were significantly associated with higher network segregation (i.e., network's tendency to divide into subnetworks; rs >0.33, ps<0.008). Alcohol use was not significantly associated with network integration (i.e., network's efficiency in combining information across the brain; ps > 0.064).CONCLUSIONS: Results provide novel evidence that alcohol use is associated with decreased rich-club connectivity and structural network disorganization. Given that both are critical in global brain communication, these results highlight the importance of examining alcohol use and brain relationships in emerging adulthood.

AB - BACKGROUND: Emerging adulthood is a critical neurodevelopmental stage, with alcohol use during this period consistently associated with brain abnormalities and damage in anatomical structure and white matter integrity. However, it is less clear how alcohol use is associated with the brain's structural organization (i.e., white matter connections between anatomical regions). Recent connectome research has focused on rich-club regions, a collection of highly-interconnected hubs that are critical in brain communication and global network organization and disproportionately vulnerable to insults.METHODS: For the first time, we examined alcohol use associations with structural rich-club and connectome organization in emerging adults (N = 66).RESULTS: Greater lifetime drinks and current monthly drinks were significantly associated with lower rich-club organization (rs =-0.38, ps < 0.003) and lower rich-club connectivity (rs <-0.34, ps < 0.007). Additionally, rich-club connectivity was significantly more negatively correlated with alcohol use than connectivity among non-rich-club regions (ps < 0.035). Examining overall structural organization, greater lifetime drinks and current monthly drinks were significantly associated with lower network density (i.e., lower network resilience; rs <-0.36, ps = 0.004). Additionally, greater lifetime drinks and current monthly drinks were significantly associated with higher network segregation (i.e., network's tendency to divide into subnetworks; rs >0.33, ps<0.008). Alcohol use was not significantly associated with network integration (i.e., network's efficiency in combining information across the brain; ps > 0.064).CONCLUSIONS: Results provide novel evidence that alcohol use is associated with decreased rich-club connectivity and structural network disorganization. Given that both are critical in global brain communication, these results highlight the importance of examining alcohol use and brain relationships in emerging adulthood.

U2 - 10.1016/j.drugalcdep.2021.109198

DO - 10.1016/j.drugalcdep.2021.109198

M3 - Article

C2 - 34861495

SN - 0376-8716

VL - 230

SP - 109198

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

ER -

Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization

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