Antibodies to skeletal muscle in myasthenia gravis. Part 1. Diagnostic value for the detection of thymoma

J B Kuks, P C Limburg, G Horst, J Dijksterhuis, H J Oosterhuis

    Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

    Samenvatting

    The role of anti-muscle antibodies (AMA) in the diagnosis of thymoma in patients with myasthenia gravis (MG) is evaluated. We compared ELISA and Western blot assay for antibodies to citric acid muscle extract (a-CAE) with an immunofluorescence assay (IF). Sera from 234 selected MG patients and 123 controls were tested. There was no essential difference between ELISA and IF. Western blot was superior in young onset patients but less useful in patients with an onset beyond the age of 40 years. Unusually high post-test probabilities were found by our patient selection criteria which seem most realistic for clinical practice. Western blot revealed no differences in specificity of AMA in thymoma and non-thymoma patients irrespective of age at onset of disease.

    Originele taal-2Engels
    Pagina's (van-tot)183-8
    Aantal pagina's6
    TijdschriftJournal of the Neurological Sciences
    Volume119
    Nummer van het tijdschrift2
    StatusGepubliceerd - nov 1993

    Vingerafdruk

    Duik in de onderzoeksthema's van 'Antibodies to skeletal muscle in myasthenia gravis. Part 1. Diagnostic value for the detection of thymoma'. Samen vormen ze een unieke vingerafdruk.

    Citeer dit