ARA1 regulates not only l-arabinose but also d-galactose catabolism in Trichoderma reesei

Tiziano Benocci, Maria Victoria Aguilar-Pontes, Roland Sándor Kun, Bernhard Seiboth, Ronald P de Vries, Paul Daly

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

Trichoderma reesei is used to produce saccharifying enzyme cocktails for biofuels. There is limited understanding of the transcription factors (TFs) that regulate genes involved in release and catabolism of l-arabinose and d-galactose, as the main TF XYR1 is only partially involved. Here, the T. reesei ortholog of ARA1 from Pyricularia oryzae that regulates l-arabinose releasing and catabolic genes was deleted and characterized by growth profiling and transcriptomics along with a xyr1 mutant and xyr1/ara1 double mutant. Our results show that in addition to the l-arabinose-related role, T. reesei ARA1 is essential for expression of d-galactose releasing and catabolic genes, while XYR1 is not involved in this process.

Originele taal-2Engels
TijdschriftFEBS Letters
DOI's
StatusGepubliceerd - 07 dec 2017

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