Samenvatting
A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.
Originele taal-2 | Engels |
---|---|
Pagina's (van-tot) | 51-57 |
Aantal pagina's | 7 |
Tijdschrift | Current Opinion in Cell Biology |
Volume | 70 |
DOI's | |
Status | Gepubliceerd - jun. 2021 |