Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome

Pim M J Rullens, Jop Kind

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveBoek/film/artikelrecensieWetenschappelijk

15 Citaten (Scopus)

Samenvatting

A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.

Originele taal-2Engels
Pagina's (van-tot)51-57
Aantal pagina's7
TijdschriftCurrent Opinion in Cell Biology
Volume70
DOI's
StatusGepubliceerd - jun. 2021

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